| Project/Area Number |
23792154
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Pathobiological dentistry/Dental radiology
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| Research Institution | Nihon University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 癌 / 遺伝子 / 間質誘導 / 脈管新生 / 腫瘍間質誘導 / DNA転写調節 |
|---|
| Research Abstract |
We investigated the effect of sodium butyrate (SB), one of histone deacetylase inhibitor on VEGF family expression in oral cancer cell line, HSC-3. Moreover, we investigated the effect of several inhibitors for AP-1, AKT and mTOR on VEGF family expression under SB stimulation.There are minimal difference in VEGF-A mRNA expression level between control and SB treated groups, however, we identified decrease of VEGF-B VEGF-C and VEGF-D mRNA expression. Moreover, angiogenic factor, angiopoientin-2 and platelet derived growth factor beta mRNA were decreased by SB treatment. These data suggest that SB inhibits stromal inducement in invasive oral carcinoma.
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