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Exhaustive analysis of the antitumor effect by suppression of vascularization that is a function of chemokine BRAK

Research Project

Project/Area Number 23792156
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Pathobiological dentistry/Dental radiology
Research InstitutionKanagawa Dental College

Principal Investigator

SUZUKI Kenji  神奈川歯科大学, 歯学部, 講師 (80350536)

Project Period (FY) 2011 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywordsケモカイン CXCL14/BRAK / 免疫沈降法 / HUVEC の細胞増殖能 / DIVAA システム / ケモカインCXCL14/BRAK / HUVECの細胞増殖能 / DIVAAシステム / ケモカイン
Research Abstract

Human needs oxygen and nourishment to live , and the blood vessel plays an important role that carries and absorbs oxygen and nourishment. Cancer is the same, and it is thought that cancer grow while forming blood vessel actively. In other words, prevention of the formation of blood vessel carrying oxygen and nourishment may stop the growth of cancer. The study group of us already discovered the protein which suppresses the growth of cancer, and it is clarified that the relations of the proteinand forming blood vessel in this study.

Report

(3 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Research-status Report
  • Research Products

    (3 results)

All 2012

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (2 results)

  • [Journal Article] Calcium-calmodulin signaling induced by epithelial cell differentiation upregulates BRAK/CXCL14 expression via the binding of SP1 to the BRAK promoter region2012

    • Author(s)
      Ikoma T, Ozawa S, Suzuki K, Kondo T, Maehata Y, Lee MC, Hata R, Kubota E
    • Journal Title

      Biochemical and biophysical Research Communications

      Volume: 420(2) Issue: 2 Pages: 217-22

    • DOI

      10.1016/j.bbrc.2012.01.157

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Presentation] Reactive oxygen species reduce the production of BRAK/CXCL14 in human head and neck squamous cell carcinoma cells2012

    • Author(s)
      Maehata Y
    • Organizer
      The EMBO meeting
    • Place of Presentation
      Nice
    • Related Report
      2012 Annual Research Report 2012 Final Research Report
  • [Presentation] 変異したP53による抗腫瘍性ケモカインBRAKの発現調節2012

    • Author(s)
      小澤重幸
    • Organizer
      第66回日本口腔科学会学術集会
    • Place of Presentation
      広島
    • Related Report
      2012 Annual Research Report 2012 Final Research Report

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Published: 2011-08-05   Modified: 2025-11-18  

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