Human applications and the comprehensive search of the metabolic syndrome specific proteins using saliva
| Project/Area Number |
23792157
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Pathobiological dentistry/Dental radiology
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| Research Institution | Kanagawa Dental College |
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Principal Investigator |
SARUTA Juri 神奈川歯科大学, 歯学研究科(研究院), 准教授 (30454151)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2013: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 唾液 / メタボローム解析 / メタボリックシンドローム / プロテオーム / プロテオーム解析 |
|---|
| Research Abstract |
We conducted the creation of rats model of metabolic syndrome of hypertension, hyperlipidemia and diabetes. We investigated the marker substances by measuring the components of the saliva in these model rats. In addition, we collected saliva of hyperlipidemia model rat, and then performed saliva proteome analysis. As a result, the saliva of hyperlipidemia rats, as compared with rats in the control group, there were 25 kinds of protein that had differences in expression 2-fold or more in both. In addition, we found that there were eight types of expression of novel proteins from these results. To determine the applicable protein analysis of human among the proteins identified in the results of these rats was promoted research for the application of human.
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Report
(4 results)
Research Products
(72 results)
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[Presentation] 不正咬合と頭痛との関連2013
Author(s)
猿田樹理, 東雅啓, 林隆司, 清水智子, 山本裕子, 松木千紗, 川嶋理恵, 近藤裕介, 槻木恵一
Organizer
第55回 歯科基礎医学会学術大会・総会
Place of Presentation
岡山
Related Report
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[Presentation] Expression of β-Defensin Using a Novel In Vivo Experimental Model2013
Author(s)
Masahiro To, Yohei Kamata, Juri Saruta, Tomoko Shimizu, Takenori Sato, Yusuke Kondo, Takashi Hayashi, Nobushiro Hamada, Keiichi Tsukinoki
Organizer
International Association for Dental Research, 91st General Session
Place of Presentation
Seattle, WA, USA
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[Presentation] ストレス負荷時のラット副腎におけるBDNFの局在についての検討2012
Author(s)
近藤裕介, 杉山弘起, 東雅啓, 林隆司, 猿田樹理, 佐藤允俊, 吉野文彦, 小林杏, 吉田彩佳, 李昌一, 槻木恵一
Organizer
第137回 神奈川歯科大学学会例会
Place of Presentation
横須賀
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