The elucidation of the role of'autophagy receptor'in immune mechanism of oral epithelium cells

• Project/Area Number: 23792158
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Pathobiological dentistry/Dental radiology
• Research Institution: Asahi University
• Principal Investigator: INOMATA Megumi 朝日大学, 歯学部, 助教 (40553798)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000); Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 感染防御機構 / オートファジー / Toll 様受容体 (TLR) / ヒト上皮細胞 / Toll様受容体(TLR) / Toll様受容体 (TLR)

Research Abstract

Recent findings have shown that autophagy regulates immune mechanism in intestinal epithelial cells. The aim of this study is to investigate whether autophagy is involved in regulation of TLR-dependent immune responses in oral epithelium cells. This studyreveals that the autophagy receptor NDP52 degrades TLR signaling molecules and downregulates TLR-mediated signaling.

Research Products

• [Journal Article] Nuclear dot protein 52, an autophagy-associated protein, regulates Toll-like receptor signaling. (2012)
  • Author(s): Inomata Megumi, and Into Takeshi.
  • Journal Title: J. Oral Biosciences Volume: 54(3) Pages: 151-154
  • URL: http://dx.doi.org/10.1016/j.job.2012.04.004
  • Peer Reviewed
• [Journal Article] Regulation of Toll-like receptor signaling by NDP52-mediated selective autophagy is normally inactivated by A20 (2012)
  • Author(s): Inomata, M., Niida, S., Shibata, K., Into, T
  • Journal Title: Cellular and Molecular Life Sciences Volume: 69 Issue: 6 Pages: 963-979
  • DOI: 10.1007/s00018-011-0819-y
  • Peer Reviewed
• [Journal Article] Autophagy in regulation of Toll-like receptor signalling (2012)
  • Author(s): Into T., Inomata M., Takayama E., Takigawa T.
  • Journal Title: Cellular Signalling Volume: 24 Issue: 6 Pages: 1150-1162
  • DOI: 10.1016/j.cellsig.2012.01.020
  • Peer Reviewed
• [Journal Article] Regulation of Toll-like receptor signaling by NDP52-mediated selective autophagy is normally inactivated by A20. (2012)
  • Author(s): Inomata M., Niida S., Shibata KI., and Into T.
  • Journal Title: Cell. Mol. Life Sci. Volume: 69(6) Pages: 963-979
  • Peer Reviewed
• [Journal Article] Nuclear dot protein 52, an autophagy-associated protein, regulates Toll-like receptor signaling (2012)
  • Author(s): Inomata M., and Into T.
  • Journal Title: Journal of Oral Biosciences Volume: 54 Issue: 3 Pages: 151-154
  • DOI: 10.1016/j.job.2012.04.004
  • Peer Reviewed
• [Presentation] Regulation of Toll-like receptor signaling by human NDP52-mediated selective autophagy (2012)
  • Author(s): Inomata Megumi, Shibata Ken-ichiro, andInto Takeshi
  • Organizer: The annual meeting of Japanese Society for Immunology
  • Place of Presentation: Chiba, JAPAN
  • Year and Date: 2012-11-27
• [Presentation] Regulation of Toll-like receptor signaling by human NDP52-mediated selective autophagy. (2012)
  • Author(s): Megumi Inomata, Ken-ichiro Shibata, and Takeshi Into
  • Organizer: The annual meeting of Japanese Society for Immunology
  • Place of Presentation: Chiba, JAPAN
  • Year and Date: 2012-11-27
• [Presentation] Regulation of Toll-like receptor signaling by NDP52-mediated selective autophagy. (2012)
  • Author(s): Inomata Megumi, and Into Takeshi
  • Organizer: 6th International Symposium on Autophagy
  • Place of Presentation: Okinawa, JAPAN
  • Year and Date: 2012-10-28 – 2012-11-01
• [Presentation] Regulation of Toll-like receptor signaling by NDP52-mediated selective autophagy (2012)
  • Author(s): Inomata Megumi and Into Takeshi.
  • Organizer: 6th International Symposium on Autophagy 2012
  • Place of Presentation: Okinawa, JAPAN
• [Presentation] Regulation of Toll-like receptor signaling by NDP52-mediated selective autophagy (2012)
  • Author(s): Megumi Inomata and Takeshi Into
  • Organizer: 6th International Symposium on Autophagy
  • Place of Presentation: Okinawa, JAPAN
• [Presentation] 引頭 毅 NDP52 は選択的オートファジーの 誘導によってToll様受容体シグナルを負に制御する (2011)
  • Author(s): 猪俣 恵 、新飯田 俊平、柴田 健一郎
  • Organizer: 第53回歯科基礎医学会学術大会・総会
  • Place of Presentation: 岐阜
  • Year and Date: 2011-10-02
• [Presentation] オートファジーによる Toll 様受容体を介した細胞内シグナル伝達の調節 (2011)
  • Author(s): 猪俣 恵 、引頭 毅
  • Organizer: 第53回歯科基礎医学会学術大会・総会
  • Place of Presentation: 岐阜
  • Year and Date: 2011-09-30
• [Presentation] オートファジーによるToll様受容体を介した細胞内シグナル伝達の調節 (2011)
  • Author(s): 猪俣 恵、引頭 毅
  • Organizer: 第53回歯科基礎医学会学術大会・総会
  • Place of Presentation: 岐阜
  • Year and Date: 2011-09-30
• [Presentation] オートファジーによる Toll様受容体を介した細胞内シグナル伝達の調節 (2011)
  • Author(s): 猪 俣 恵、引 頭 毅
  • Organizer: 第53回歯科基礎医学会学術大会・総会
  • Place of Presentation: 岐阜
• [Presentation] NDP52は選択的オートファジーの誘導によってToll様受容体シグナルを負に制御する (2011)
  • Author(s): 猪俣 恵、新飯田 俊平、柴田 健一郎、引頭 毅
  • Organizer: 第53回歯科基礎医学会学術大会・総会
  • Place of Presentation: 岐阜
• [Presentation] ヒトNDP52による選択的オートファジーの誘導を介したToll様受容体シグナルの制御 (2011)
  • Author(s): 猪俣 恵、柴田 健一郎、引頭 毅
  • Organizer: 第40回日本免疫学会学術集会
  • Place of Presentation: 千葉
• [Remarks] 朝日大学歯学部口腔感染医療学講座口腔微生物学分野ホームページ
  • URL: http://scw.asahi-u.ac.jp/~bac/index.html
• [Remarks] 朝日大学 歯学部 口腔感染医療学講座 口腔微生物分野
  • URL: http://scw.asahi-u.ac.jp/~bac/index.html