The elucidation of the role of'autophagy receptor'in immune mechanism of oral epithelium cells
| Project/Area Number |
23792158
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Pathobiological dentistry/Dental radiology
|
|---|
| Research Institution | Asahi University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2011 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
|---|
| Keywords | 感染防御機構 / オートファジー / Toll 様受容体 (TLR) / ヒト上皮細胞 / Toll様受容体(TLR) / Toll様受容体 (TLR) |
|---|
| Research Abstract |
Recent findings have shown that autophagy regulates immune mechanism in intestinal epithelial cells. The aim of this study is to investigate whether autophagy is involved in regulation of TLR-dependent immune responses in oral epithelium cells. This studyreveals that the autophagy receptor NDP52 degrades TLR signaling molecules and downregulates TLR-mediated signaling.
|
Report
(4 results)
Research Products
(18 results)
