Effects of degraded dentin matrix proteins on the repair process of dentin-pulp complex
| Project/Area Number |
23792170
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Conservative dentistry
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| Research Institution | Osaka University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 歯髄 / 象牙質 / 修復象牙質 / 第三象牙質 / 象牙質-歯髄複合体 / MMP / 歯学 |
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| Research Abstract |
The objective of this study was to elucidate the wound healing mechanism of dentin-pulp complex. We investigated the effects of degraded dentin matrix proteins (DMPs) induced by acids or proteinases on the function of pulp cells. External acid or internal MMP molecules were found to degrade DMPs and pulp cells were promoted their proliferation or differentiation by degraded DMPs. These results indicated that degraded DMPs potentially affected the healing process of dentin-pulp complex.
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Report
(3 results)
Research Products
(19 results)
