Development of a new adhesive system to reduce degradation on resin-dentin interface

• Project/Area Number: 23792175
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Conservative dentistry
• Research Institution: Okayama University
• Principal Investigator: NISHITANI Yoshihiro 岡山大学, 大学院・医歯薬学総合研究科, 准教授 (60325123)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2011: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
• Keywords: 象牙質 / 接着強さ / マトリックスメタロプロテアーゼ / 象牙質引張接着強さ / 象牙質コラーゲン / セルフエッチングアドヒーシブ / 架橋剤 / コラーゲン分解酵素

Research Abstract

It was suggested that adhesive systems incorporated 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide hydrochloride ） and/or chlorhexidine reduced latent enzymatic activities in dentin and dentin bond strengths after long- term water storage.

Research Products

• [Journal Article] Effect of phosphoric acid on the degradation of human dentin matrix (2013)
  • Author(s): Tezvergil-Mutluay A, Mutluay M, Seseogullari-Dirihan R, Agee KA, Key WO, Scheffel DL, Breschi L, Mazzoni A, Tjaderhane L,Nishitani Y, Tay FR, Pashley DH
  • Journal Title: Journal of Dental Research Volume: Vol.92 Pages: 87-91
  • Peer Reviewed
• [Journal Article] Effect of phosphoric acid on the degradation of human dentin matrix. (2013)
  • Author(s): Tezvergil-Mutluay A
  • Journal Title: Journal of Dental Research Volume: 92 Issue: 1 Pages: 87-91
  • DOI: 10.1177/0022034512466264
  • Peer Reviewed
• [Journal Article] The inhibitory effects of quaternary ammonium methacrylates on soluble and matrix-bound MMPs (2011)
  • Author(s): Tezvergil-Mutluay A, Agee KA, Uchiyama T, Imazato S, Mutluay MM, Cadenaro M, Breschi L, Nishitani Y, Tay FR, Pashley DH
  • Journal Title: Journal of Dental Research Volume: Vol.90,No.4 Pages: 535-540
  • Peer Reviewed
• [Journal Article] The inhibitory effects of quaternary ammonium methacrylates on soluble and matrix-bound MMPs. (2011)
  • Author(s): Tezvergil-Mutluay A, Agee KA, Uchiyama T, Imazato S, Mutluay MM, Cadenaro M, Breschi L, Nishitani Y, Tay FR, Pashley DH.
  • Journal Title: Journal of Dental Research Volume: 90 Issue: 2 Pages: 535-540
  • DOI: 10.1177/0022034511427705
  • Peer Reviewed
• [Presentation] Effects of Quaternary-Ammonium-Methacrylates on the Fracture Toughness of Resin Beams (2012)
  • Author(s): Hoshika Tomohiro
  • Organizer: The 90th General Session & Exhibition of the International Association of Dental Research
  • Place of Presentation: Iguacu Falls, Brazil
  • Year and Date: 2012-06-22
• [Presentation] Effects of Quaternary-Ammonium-Methacrylates on the Fracture Toughness of Resin Beams (2012)
  • Author(s): Hoshika T.
  • Organizer: The 90th General Session & Exhibition of the International Association of Dental Research
  • Place of Presentation: イグアスフォールズ、ブラジル
• [Presentation] Mineralization of resin using experimental adhesives containing hydroxyapatite (2011)
  • Author(s): Hoshika Tomohiro
  • Organizer: 41th American Association for Dental Research Annual Meeting
  • Place of Presentation: Tampa, Florida, USA
  • Year and Date: 2011-03-22
• [Presentation] Mineralization of resin using experimental adhesives containing hydroxyapatite
  • Author(s): Hoshika T, Nishitani Y, Pashley D, Yoshiyama M
  • Organizer: American Association for Dental Research 41th Annual Meeting
  • Place of Presentation: タンパ，アメリカ合衆国
• [Remarks]
  • URL: http://opera.dent.okayama-u.ac.jp/