The generation of ameloblasts from adult tissue-delivered cells and the method of the tooth germ regenration
| Project/Area Number |
23792176
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Conservative dentistry
|
|---|
| Research Institution | Hiroshima University |
|---|
Principal Investigator |
SUZUKI Shigeki 広島大学, 医歯薬保健学研究院, 助教 (30549762)
|
|---|
| Project Period (FY) |
2011 – 2013
|
| Project Status |
Completed (Fiscal Year 2013)
|
| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2013: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2011: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
|
|---|
| Keywords | 象牙芽細胞 / DMP-1 / DSPP / 保存修復 / 口腔粘膜上皮 |
|---|
| Research Abstract |
The original main purpose of this research project was the identification of the factors that induce epithelial-mesenchymal interaction during tooth development. However, it was difficult to isolate and cultivate oral epithelial cells. Since it has been suggested that the enamel and dentin extracellular matrix (ECM) proteins would be able to regulate ameloblasts and odontoblasts differentiation in vitro, we generated the recombinant proteins of tooth ECM proteins and analyzed their effects for mesenchymal stem cells (MSCs) adhesion and differentiation. DMP-1 was able to induce MSCs adhesion and differentiation into osteogenic lineage cells while intact DPP was unable to. Thus, the functions of these proteins may be modulated by proteolytic cleavages by unknown extracellular proteases.
|
Report
(4 results)
Research Products
(13 results)
-
[Journal Article] The Inflammation-lipocalin2 axis may contribute to the development of chronic kidney disease2014
Author(s)
Hashikata, A., Yamashita, A., Suzuki, S., Nagayasu, S., Shinjo, T., Taniguchi, A., Fukushima, M., Nakai, Y., Nin, K., Watanabe, N., Asano, T., Abiko, Y., Kushiyama, A., Nagasaka, S., and Nishimura, F.
-
Journal Title
Nephrol Dial Transplant
Volume: 29(3)
Pages: 611-618
Related Report
Peer Reviewed
-
[Journal Article] The Inflammation-lipocalin2 axis may contribute to the development of chronic kidney disease.2014
Author(s)
Hashikata, A., Yamashita, A., Suzuki, S., Nagayasu, S., Shinjo, T., Taniguchi, A., Fukushima, M., Nakai, Y., Nin, K., Watanabe, N., Asano, T., Abiko, Y., Kushiyama, A., Nagasaka, S., and *Nishimura, F.
-
Journal Title
Nephrol Dial Transplant.
Volume: 29
Pages: 611-618
Related Report
Peer Reviewed
-
-
-
[Journal Article] Smoking and adipose tissue inflammation suppress leptin expression in Japanese obese males : Potential mechanism of resistance to weight loss among Japanese obese smokers2012
Author(s)
Nagayasu S, Suzuki S, Yamashita A, Taniguchi A, Fukushima M, Nakai Y, Nin K, Watanabe N, Nagasaka S, Yabe D, Nishimura F
-
Journal Title
Tob Induc Dis
Volume: 10
Issue: 1
Pages: 3-3
DOI
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
