Analysis of outbreak mechanism of the pain on dentin-pulp complex.
Project/Area Number |
23792178
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Conservative dentistry
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Research Institution | Kagoshima University |
Principal Investigator |
Tatsuyama Shoko 鹿児島大学, 医歯学域医学部・歯学部附属病院, 助教 (70347095)
|
Project Period (FY) |
2011-04-28 – 2016-03-31
|
Project Status |
Completed (Fiscal Year 2015)
|
Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
Keywords | TRPM8 / 象牙芽細胞 / 温度感受性受容体 / 温度感覚性受容体 / 歯髄細胞 / 歯髄・象牙芽細胞複合体 / VR-1 / 温度感受性イオンチャンネル / 象牙質歯髄複合体 / 歯随細胞 / TRPV88 / 象牙質歯随複合体 |
Outline of Final Research Achievements |
In this study, we confirmed the expression of the transient receptor potential melastatin-8 (TRPM8) in human dental pulp cells and in mouse odontoblasts. Using rat dental pulp slice culture as a dentin-pulp complex models we further revealed TRPM8 expression in rat odontoblasts. Our results indicated that odontoblasts could directly respond to noxious stimuli, example as cold condition, and transduce the signal to the nearby nerves, accordingly odontblasts may be involved in dentin hypersensitivity.
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Report
(6 results)
Research Products
(1 results)
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[Journal Article] Dentin and pulp sense cold stimulus.2015
Author(s)
Tokuda M, Tatsuyama S, Fujisawa M, Morimoto-Yamashita Y, Kawakami Y, Shibukawa Y, Torii M.
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Journal Title
Medical Hypotheses
Volume: 84
Issue: 5
Pages: 442-444
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant