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Mechanoregulation of periodontal ligament homeostasis by primary cilia

Research Project

Project/Area Number 23792213
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Prosthetic dentistry
Research InstitutionNiigata University

Principal Investigator

KAKU sakiko  新潟大学, 医歯学総合病院, 医員 (60584589)

Project Period (FY) 2011 – 2012
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords歯根膜 / メカニカルストレス / プライマリー・シリア / プライマリーシリア / メカノレセプター
Research Abstract

It is evident that mechanical stress contributes the tissue homeostasis of periodontal ligament (PDL). In this study, we explore the distribution and mechanoresponse of primary cilia, a possible mechanosensor in PDL. The anti-acetylated tubulin positive primary cilia were detected in PDL. The primary cilia was preferentially distributed at the cementum side of PDL. The excessive occlulsal loading condition increased the number of primary cilia. These results indicate that the preferential distribution of primary cilia may contribute the site specific mechanoresponse of the PDL.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (3 results)

All 2013 2012 Other

All Presentation (3 results)

  • [Presentation] 歯根膜の部位によるプライマリー・シリア出現率の違いと過剰咬合による変化2013

    • Author(s)
      井田貴子、加来賢、野澤恩美、Rosales Rocabado JM、加来咲子、魚島勝美
    • Organizer
      日本補綴歯科学会
    • Place of Presentation
      福岡
    • Year and Date
      2013-05-18
    • Related Report
      2013 Final Research Report
  • [Presentation] 歯根膜部位別におけるプライマリー・シリアの出現率と過剰咬合によるその変化2012

    • Author(s)
      井田貴子,加来 賢,野沢恩美,Rosales Juan Marcelo,加来咲子,魚島勝美
    • Organizer
      第122回日本補綴歯科学会
    • Place of Presentation
      福岡
    • Related Report
      2012 Research-status Report
  • [Presentation] 歯根膜の部位によるプライマリーシリア出現率の違いと過剰咬合による変化

    • Author(s)
      井田貴子,加来 賢,野澤恩美,Rosales Rocabado JM,加来咲子,魚島勝美
    • Organizer
      日本補綴歯科学会学術大会
    • Place of Presentation
      福岡
    • Related Report
      2013 Annual Research Report

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Published: 2011-08-05   Modified: 2019-07-29  

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