Mechanoregulation of periodontal ligament homeostasis by primary cilia

Research Project

Project/Area Number	23792213
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Prosthetic dentistry
Research Institution	Niigata University
Principal Investigator	KAKU sakiko 新潟大学, 医歯学総合病院, 医員 (60584589)
Project Period (FY)	2011 – 2012
Project Status	Completed (Fiscal Year 2013)
Budget Amount *help	¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000) Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000) Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords	歯根膜 / メカニカルストレス / プライマリー・シリア / プライマリーシリア / メカノレセプター
Research Abstract	It is evident that mechanical stress contributes the tissue homeostasis of periodontal ligament (PDL). In this study, we explore the distribution and mechanoresponse of primary cilia, a possible mechanosensor in PDL. The anti-acetylated tubulin positive primary cilia were detected in PDL. The primary cilia was preferentially distributed at the cementum side of PDL. The excessive occlulsal loading condition increased the number of primary cilia. These results indicate that the preferential distribution of primary cilia may contribute the site specific mechanoresponse of the PDL.

Report

(4 results)