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Development of the effective bone augmentation using intracellular transfection of anti-apoptosis protein HSP27

Research Project

Project/Area Number 23792215
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Prosthetic dentistry
Research InstitutionNiigata University

Principal Investigator

KAWASAKI Maiko  新潟大学, 医歯学総合病院, 助教 (40584587)

Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
KeywordsHSP27 / 骨芽細胞 / アポトーシス / トランスフェクション法 / 骨増成 / 細胞移植
Research Abstract

In the present study, to explore a new way of cell transplantation for bone augmentation, we evaluate the application of HSP27, an anti-apoptotic protein to the transplanted cell. The over expression of HSP27 did not affect the cell proliferation and mineralization ability of osteoblast, however, apoptosis was diminished by the over expression of HSP27. Furthermore, transplanted cell apoptosis was also inhibited and proliferation marker expressing cells were increased at the initial stage of cell transplantation.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (8 results)

All 2014 2013 2012

All Journal Article (8 results) (of which Peer Reviewed: 8 results,  Open Access: 1 results)

  • [Journal Article] R-spondins/Lgrs expression in tooth development.2014

    • Author(s)
      Kawasaki M, Porntaveetus T, Kawasaki K, Oommen S, Otsuka-Tanaka Y, Hishinuma M, Nomoto T, Maeda T, Takubo K, Suda T, Sharpe PT, Ohazama A.
    • Journal Title

      Dev Dyn.

      Volume: 243 Issue: 6 Pages: 844-851

    • DOI

      10.1002/dvdy.24124

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Adult Human Gingival Epithelial Cells as a Source for Whole-tooth Bioengineering.2013

    • Author(s)
      Angelova Volponi Ana, Kawasaki Maiko
    • Journal Title

      Journal of Dental Research

      Volume: 92(4) Issue: 4 Pages: 329-334

    • DOI

      10.1177/0022034513481041

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Multiple postnatal craniofacial anomalies are characterized by conditional loss of polycystic kidney disease 2 (Pkd2).2013

    • Author(s)
      Khonsari H Roman, Kawasaki Maiko
    • Journal Title

      Human Molecular Genetics

      Volume: 22(9) Issue: 9 Pages: 1873-1885

    • DOI

      10.1093/hmg/ddt041

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] The buccohypophyseal canal is an ancestral vertebrate trait maintained by modulation in sonic hedgehog signaling2013

    • Author(s)
      Khonsari RH, Seppala M, Pradel A, Dutel H, Clément G, Lebedev O, Ghafoor S, Rothova M, Tucker A, Maisey JG, Fan CM, Kawasaki M, Ohazama A, Tafforeau P, Franco B, Helms J, Haycraft CJ, David A, Janvier P, Cobourne MT, Sharpe PT
    • Journal Title

      BMC Biol

      Volume: 11(1) Pages: 27-27

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] The buccohypophyseal canal is an ancestral vertebrate trait maintained by modulation in sonic hedgehog signaling.2013

    • Author(s)
      Khonsari H Roman, Kawasaki Maiko
    • Journal Title

      BMC Biology

      Volume: 11(1) Pages: 27-27

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Oral lining mucosa development depends on mesenchymal microRNAs.2012

    • Author(s)
      Otsuka-Tanaka Yoko, Oommen Shelly, Kawasakia Maiko
    • Journal Title

      Journal of Dental Research

      Volume: 92(3) Issue: 3 Pages: 229-234

    • DOI

      10.1177/0022034512470830

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Cytoplasmic plaque formation in hemidesmosome development is dependent on SoxF transcription factor function.2012

    • Author(s)
      Oommen Shelly, Kawasaki Maiko
    • Journal Title

      PLOS ONE

      Volume: 7(9) Issue: 9 Pages: e43857-e43857

    • DOI

      10.1371/journal.pone.0043857

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Distinct roles of microRNAs in epithelium and mesenchyme during tooth development.2012

    • Author(s)
      Oommen Shelly, Otsuka-Tanaka Yoko, Kawasaki Maiko
    • Journal Title

      Developmental Dynamics

      Volume: 241(9) Issue: 9 Pages: 1465-1472

    • DOI

      10.1002/dvdy.23828

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed

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Published: 2011-08-05   Modified: 2019-07-29  

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