Development of controlled release of vancomycin sol-gel films on titanium abutment

• Project/Area Number: 23792219
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Prosthetic dentistry
• Research Institution: Osaka University
• Principal Investigator: KOBAYASHI Yasuyoshi 大阪大学, 歯学部附属病院, 医員 (50448114)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: インプラント / 表面加工 / チタン合金 / チタン / 抗菌加工

Research Abstract

Sol-gel films on titanium alloy have made with vancomycin solution. In the solution of more than 10% weight concentration vancomycin, about three weeks was confirmed in the study of controlled release drug release of the film.In the morphological analysis, the stability of the films can be acquired at a thickness of 200nm revealed.To investigate the antibacterial coating, we examined the effect on the formation of the inhibition rings by immersion in a saliva 37 ℃. Formation of inhibition rings was reduced after 14 days.