Periodontal regeneration by collagen scaffold in combination with FGF-2
| Project/Area Number |
23792266
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Dental engineering/Regenerative dentistry
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| Research Institution | Hokkaido University |
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Principal Investigator |
KATO Akihito 北海道大学, 歯学研究科(研究院), 助教 (40507571)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2013: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 歯周組織再生 / 線維芽細胞増殖因子（FGF2） / スキャフォールド / コラーゲンハイドロゲル / 分岐部病変 / tissue engineering / 動物実験 / ビーグル犬 / 線維芽細胞増殖因子(FGF2) / Tissue engineering / FGF-2 / コラーゲンスポンジ / 再生医学 / コラーゲン |
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| Research Abstract |
We examined whether combined therapy of fibroblast growth factor 2 (FGF-2) induced wound healing and collagen hydrogel scaffold stimulated periodontal regeneration. Collagen hydrogel scaffold has rapid cell infiltration in the scaffold and replacement by regenerative tissue with low cytotoxicity. Implantation of collagen hydrogel scaffold in combination with FGF-2 enhanced regeneration of alveolar bone, cementum, periodontal ligament in beagle dogs. The combined therapy is expected to be a suitable therapy for periodontal tissue engineering.
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Report
(4 results)
Research Products
(21 results)
