| Project/Area Number |
23792270
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Dental engineering/Regenerative dentistry
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| Research Institution | Tohoku University |
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Principal Investigator |
SHIRAISHI Naru 東北大学, 東北メディカル・メガバンク機構, 助教 (60585355)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 低弾性インプラント / ストレスシールディング / 表面改質 / RFマグネトロンスパッタリング / メカニカルストレス / インプラント / 低弾性 |
|---|
| Research Abstract |
Ti29Nb13Ta4.6Zr alloy (TNTZ) has excellent advantages as a biomaterial, such as low Young's modulus and cytotoxicity, and the absence of allergens. However, it is unclear whether TNTZ can achieve sufficient osseointegration to be used as a dental implant. The advantageous effect of surface modification of TNTZ implants by radiofrequency (RF) magnetron sputtering is also unclear. I investigated the biomechanical behaviors of TNTZ implants in vivo, using cylindrical implants of four types: pure Ti, TNTZ, and pure Ti and TNTZ coated with calcium phosphate (CaP). The implants were inserted in rat femurs, and the femurs were subjected to biomechanical analyses after various time intervals. The results suggest that TNTZ implants can achieve osseointegration similar to that of pure Ti, and that surface modification with CaP by RF magnetron sputtering improves osseointegration.
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