| Project/Area Number |
23792272
|
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Dental engineering/Regenerative dentistry
|
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| Research Institution | Osaka Dental University (2012)
Tohoku University (2011) |
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Principal Investigator |
|
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| Project Period (FY) |
2011 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2012: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
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| Keywords | 情報工学 / BMP-2 / 骨再生 / 幹細胞 / 再生医学 / 歯学 / 人工知能 / 骨 / 複合薬 / 最適化 |
|---|
| Research Abstract |
I established a novel expeditious drug screening approach, Feedback system control (FSC) with differential evolution, to search for optimal drug cocktails that induced osteoblastogenesis of mesenchymal stem cells. With an adequate biomarker, FSC process robustly elicited prospective drug cocktails containing bone morphogenic protein 2 (BMP-2), which concentration was lower than one hundredth of conventional osteogenic media.
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