Pioneering research of the effect of Bisphosphonate to achieved osseointegrated implants

Research Project

Project/Area Number	23792278
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Dental engineering/Regenerative dentistry
Research Institution	Osaka University
Principal Investigator	WADA Masahiro 大阪大学, 大学院・歯学研究科, 助教 (20452451)
Project Period (FY)	2011 – 2012
Project Status	Completed (Fiscal Year 2012)
Budget Amount *help	¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000) Fiscal Year 2012: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000) Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords	歯科インプラント / ビスフォスフォネート製剤 / ビスフォスフォネート / インプラント
Research Abstract	After establish the ossointegration model with rat, examine about the effect of Bisphosphonate (BP) to this model. In result, removable torque was increased by administration of BP at immediately after administration of BP and 3 month later. On the otherhand, Bone resorption marker : NTX was decreased at the immediately after administration of BP, and was increased at the 3 month. Therefore, administration of BP affect the bone kinetic around the osseointegrated implant.