| Project/Area Number |
23792289
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Dental engineering/Regenerative dentistry
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| Research Institution | Health Sciences University of Hokkaido |
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Principal Investigator |
TAKEBE Futami 北海道医療大学, 歯学部, 助教 (10534448)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
|
| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2013: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2011: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
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| Keywords | インプラント / ラクトフェリン / 細菌付着 / 抗菌性 |
|---|
| Research Abstract |
Dental implants have been recognized as an effective treatment for the loss of teeth. However, biological and technical complications frequently occur because dental implant abutments are located at trans mucosal sites. The aim of the present study was to inhibit bacterial accumulation on dental implant, especially abutment surfaces to prevent peri-implantitis. We examined the effects of human lactoferrin (LF), an antibacterial protein present in saliva, as an antibacterial coating on the titanium surface and evaluated its effects on oral bacterial adhesion.We found that LF coated surface inhibited S. gordonii, P. gingivalis, and F. nucleatum adhesion showing the positive possibility for clinical application.
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