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Surface modification for anti-bacterial effect on titanium implant

Research Project

Project/Area Number 23792289
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Dental engineering/Regenerative dentistry
Research InstitutionHealth Sciences University of Hokkaido

Principal Investigator

TAKEBE Futami  北海道医療大学, 歯学部, 助教 (10534448)

Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2013: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2011: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Keywordsインプラント / ラクトフェリン / 細菌付着 / 抗菌性
Research Abstract

Dental implants have been recognized as an effective treatment for the loss of teeth. However, biological and technical complications frequently occur because dental implant abutments are located at trans mucosal sites. The aim of the present study was to inhibit bacterial accumulation on dental implant, especially abutment surfaces to prevent peri-implantitis. We examined the effects of human lactoferrin (LF), an antibacterial protein present in saliva, as an antibacterial coating on the titanium surface and evaluated its effects on oral bacterial adhesion.We found that LF coated surface inhibited S. gordonii, P. gingivalis, and F. nucleatum adhesion showing the positive possibility for clinical application.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (10 results)

All 2014 2013 2012

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (9 results)

  • [Journal Article] Inhibition of initial bacterial adhesion on titanium surfaces by lactoferrin coating2014

    • Author(s)
      Futami Nagano-Takebe, Hiroshi Miyakawa, Futoshi Nagazawa, Kazuhiko Endo
    • Journal Title

      Biointerphases

      Volume: 9 (in press) Issue: 2

    • DOI

      10.1116/1.4867415

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Presentation] ラクトフェリン吸着による口腔インプラントアバットメントへの細菌の付着抑制-吸着・脱着に関する検討-2014

    • Author(s)
      建部二三, 井田有亮, 戸島洋和, 遠藤一彦
    • Organizer
      第63回日本歯科理工学会学術講演会
    • Place of Presentation
      東京
    • Year and Date
      2014-04-12
    • Related Report
      2013 Final Research Report
  • [Presentation] ラクトフェリン吸着による口腔インプラントアバットメントへの細菌の付着抑制‐吸着・脱着に関する検討‐2014

    • Author(s)
      建部二三,井田有亮,戸島洋和,遠藤一彦
    • Organizer
      日本歯科理工学会 第63回学術講演会
    • Place of Presentation
      船堀タワーホール
    • Related Report
      2013 Annual Research Report
  • [Presentation] Inhibition of initial bacterial adhesion to titanium by lactoferrin2013

    • Author(s)
      Futami Nagano-Takebe, Hiroshi Miyakawa, Futoshi Nakazawa, Kazuhiko Endo
    • Organizer
      The 4th International Symposium on Surface and Interface of Biomaterials
    • Place of Presentation
      ローマ
    • Year and Date
      2013-09-27
    • Related Report
      2013 Final Research Report
  • [Presentation] 酸性フッ化物溶液による口腔インプラントアバットメント材料の腐食とラクトフェリン吸着による細菌の付着抑制について2013

    • Author(s)
      建部二三, 赤沼正康, 橋本正則, 井田有亮, 越智守生, 遠藤一彦
    • Organizer
      第61回日本歯科理工学会学術講演会
    • Place of Presentation
      東京
    • Year and Date
      2013-04-14
    • Related Report
      2013 Final Research Report
  • [Presentation] 酸性フッ化物溶液による口腔インプラントアバットメント材料の腐食とラクトフェリン吸着による細菌の付着抑制について2013

    • Author(s)
      建部二三,赤沼正康,橋本正則,井田有亮,越智守生,遠藤一彦
    • Organizer
      日本歯科理工学会 第61回学術講演会
    • Place of Presentation
      船堀タワーホール
    • Related Report
      2013 Annual Research Report
  • [Presentation] Inhibition of initial bacterial adhesion to titanium by lactoferrin2013

    • Author(s)
      F Nagano-Takebe, H Miyakawa, F Nakazawa, K Endo
    • Organizer
      The 4th International Symposium on Surface and Interface of Biomaterials
    • Place of Presentation
      The Faculty of Engineering of the University La Sapienza
    • Related Report
      2013 Annual Research Report
  • [Presentation] ラクトフェリン吸着による口腔インプラントアバットメントへの細菌の付着抑制2012

    • Author(s)
      長野二三, 橋本正則, 井田有亮, 戸島洋和, 遠藤一彦
    • Organizer
      第60回日本歯科理工学会学術講演会
    • Place of Presentation
      福岡
    • Year and Date
      2012-10-13
    • Related Report
      2013 Final Research Report 2012 Research-status Report
  • [Presentation] 歯科用インプラントアバットメント材料の表面に結合したラクトフェリンによる細菌の付着抑制に関する検討2012

    • Author(s)
      長野二三, 井田有亮, 橋本正則, 遠藤一彦
    • Organizer
      第59回日本歯科理工学会学術講演会
    • Place of Presentation
      徳島
    • Year and Date
      2012-04-14
    • Related Report
      2013 Final Research Report
  • [Presentation] 歯科用インプラントアバットメント材料の表面に結合したラクトフェリンによる2012

    • Author(s)
      長野二三,井田有亮,橋本正則,遠藤一彦
    • Organizer
      第59回日本歯科理工学会学術講演会
    • Place of Presentation
      徳島
    • Related Report
      2012 Research-status Report

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Published: 2011-08-05   Modified: 2019-07-29  

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