| Project/Area Number |
23792292
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Dental engineering/Regenerative dentistry
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| Research Institution | Meikai University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
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| Keywords | ハイドロキシアパタイト / チタン / 複合材料 / 骨芽細胞 / Ti/Hap複合材料 / 圧縮せん断法 |
|---|
| Research Abstract |
In the present study, there is a possibility that composites of Ti-HA were prepared by adding compressive shearing stress the adhesion proliferation of osteoblastic cells on the composites was investigated in culture cell experiments. The adhesionproliferation of MC3T3-E1 cultured cells on the composites was inversely suppressed by the increase in HA content. The inhibitory action of HA on the cell proliferation was not due to the released component from it materials, but rather the surface properties of the materials may beinvolved in this mechanism. These results suggest that the HA itself may inhibit the cell growth, but the compounds partially formed from HA by the 1100℃-sintering heat may induce cell growth slightly. The activity of cell proliferation may be entirely different by the nature of apatite.
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