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Three-dimensional examination of biological stability of the bone surrounding dental implants

Research Project

Project/Area Number 23792298
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Dental engineering/Regenerative dentistry
Research InstitutionThe Nippon Dental University

Principal Investigator

TSUJIMURA Maiko  日本歯科大学, 新潟生命歯学部, 講師 (60535219)

Project Period (FY) 2011-04-28 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2013: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywordsインプラント / 歯学 / 細胞・組織 / 骨細胞 / リモデリング
Outline of Final Research Achievements

Since the surrounding bone around an implant should be a crucial component for satisfactory implantation, this study aimed to examine a histological alteration of the bone tissue around titanium implants in rats. We investigated the bone around the implants by using micro-CT imaging, bone labeling, and immunostaining for certain molecules that were associated with the mineralization and bone remodeling. The bone remodeling influenced the healing of the bone around the implant judging from the micro-CT images and three-dimensional images of the labeled bone using confocal laser-scanning microscopy. Moreover, the immunohistochemical data indicated that the condition of the bone matrix around the implants had a close relation with osteocytes in the surrounding bone. The osteocytes seem to play an important role in the healing process of the bone around the implants as a local regulator of bone remodeling, which supports the prognosis of the dental implantation.

Report

(5 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (3 results)

All 2015 2014 Other

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (2 results)

  • [Journal Article] Periosteum-induced Bone Formation by Distraction Osteogenesis: Histologic and Micro-CT Analysis2015

    • Author(s)
      Ken Nakahara, Maiko Haga-Tsujimura, Tateyuki Iizuka, Nikola Saulacic
    • Journal Title

      The International Journal of Oral & Maxillofacial Implants

      Volume: 印刷中

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Presentation] 骨改造を制御するインプラント周囲細胞の免疫組織化学的検討2014

    • Author(s)
      辻村麻衣子, 中原賢, 吉江紀夫
    • Organizer
      第44回公益社団法人日本口腔インプラント学会学術大会
    • Place of Presentation
      東京国際フォーラム(東京都 千代田区)
    • Year and Date
      2014-09-13 – 2014-09-14
    • Related Report
      2014 Annual Research Report
  • [Presentation] インプラント周囲骨細胞の免疫組織化学的検索

    • Author(s)
      羽下-辻村麻衣子
    • Organizer
      第54回歯科基礎医学会学術大会・総会
    • Place of Presentation
      奥羽大学記念講堂(福島県郡山市)
    • Related Report
      2012 Research-status Report

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Published: 2011-08-05   Modified: 2019-07-29  

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