Downregulation of Parathyroid Hormone Receptor 1 expression suppresses tumor metastasis in oral cancer.
| Project/Area Number |
23792313
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Surgical dentistry
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| Research Institution | Tohoku University (2012)
Yamagata University (2011) |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 口腔癌 / 遺伝子 / 転移 / ホルモン受容体 |
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| Research Abstract |
I. We examined the expression of PTHR1 mRNA and protein in oral cancer cell lines. PTHR1 is overexpressed in oral cancer cells.
II. Comparing PTHR1 expression level, no correlation was found between oral cancer cell lines with high metastatic potential and those with low or non metastatic one.
III. And cancer cells were strongly positive for PTHR1 staining in oral cancer clinical samples.
IV. Moreover, the expression level of PTHR1 in cases with metastasis is higher than that of those with non metastasis.
V. We established PTHR1 overexpressed oral cancer cell lines. The cell lines with high expression of PTHrP showed rapid growth.
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Report
(3 results)
Research Products
(9 results)
