| Project/Area Number |
23792329
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Surgical dentistry
|
|---|
| Research Institution | Hamamatsu University School of Medicine |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2011 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
|
|---|
| Keywords | 口腔扁平上皮癌 / 免疫担当細胞 / 口腔癌 / リンパ球 / ケモカイン |
|---|
| Research Abstract |
Regulatory T cells are known to suppress tumore immunity in tumor tissues.In recent years, the role of CD8+ T cells has attracted attention in addeition to CD4+ regulator y T cells. Accordingly, the relationship between local CD8+ T ccells in oral squamous cell carcinoma and the pathological condieion thereof was investigated. As a result, it was found that PD -1+ CD8+ T cells, which make up a regulatory lymphocyte subset, were specifically invading inside the cancer cell nest of oral squmous cell carcinoma. This is in contrast to the presence of CD4+ regulatory T cells in the stroma of cancer, and it has been suggested that PD-1+ CD8+ T cells and CD4+ regulatory T cells in the stroma of cancer, and it has been suggested that PD-1+ CD8+ T cells and CD4+ regulatory T cells play different roles regarding the immunosuppression of tumors.
|
