The mechanism of neuropathic pain and effects of neurotrophic factor in the orofacial area

• Project/Area Number: 23792336
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Surgical dentistry
• Research Institution: Osaka University (2012); Research Institute, Osaka Medical Center for Maternal and Child Health (2011)
• Principal Investigator: OYAMAGUCHI Aiko 大阪大学, 歯学部附属病院, 医員 (70464237)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000); Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
• Keywords: 歯科麻酔学 / 神経因性疼痛 / 神経栄養因子 / c-Fos / IB4 / 免疫組織化学染色 / 疼痛関連行動

Research Abstract

The non-peptidergic fibers in the trigeminal subnucleus caudalis (Vc) decreased after IB4 Saporin injection into the cisterna magna. This study examined formalin-induced pain-related behavior (PRB) in the upper lip and c-Fos expression. In IB4-Saporin-pretreated rats, the formalin-induced PRB was significantly increased compared with those of control rats. The numbers of c-Fos-immunoreactive cells increased compared with those of control rats. In IB4-Saporin-pretreated rats, the formalin-induced PRB after artemin injection in the upper lip was significantly decreased compared with those of saline injection rats.