Development of the molecular target medicine for oral squamous cell carcinoma by the heat shock transcription factor control

Research Project

Project/Area Number	23792349
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Surgical dentistry
Research Institution	Yamaguchi University
Principal Investigator	HORINAGA Daiju 山口大学, 医学部附属病院, 助教 (30379987)
Project Period (FY)	2011 – 2012
Project Status	Completed (Fiscal Year 2012)
Budget Amount *help	¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000) Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000) Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords	HSF1
Research Abstract	I performed effect measurement of an antitumor effect by knockdown in in vitro in CDDP alone using the oral cancer cell, thermotherapy alone, a heat shock transcription factor. I did not significantly accept the reinforcement of the effect in CDDP+KD though I accepted an addition effect in CDDP+HS, HS+KD, but significantly recognized synergy in the tripartite combination group of CDDP+HS+KD. In addition, I knocked down the common gene which caused a drop of the gene expression because knockdown did HSF1 in three kinds of cancer cells strain. Although there was not it, as for the result, as for the cytostasis effect like HSF1, both cytostasis effects were reinforced by the knockdown by the combination.

Report

(3 results)