The reductive mobilization of iron and the effects of localanesthetics on oxidative stress

• Project/Area Number: 23792350
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Surgical dentistry
• Research Institution: The University of Tokushima
• Principal Investigator: TAKAISHI Kazumi 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 助教 (20325286)
• Co-Investigator(Renkei-kenkyūsha): AKI Kenji 徳島文理大学, 研究科学研究所, 教授 (20035405) ; KITAHATA Hirsohi 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 教授 (60161486)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: 歯科麻酔学 / 鉄イオン / フェリチン / 還元 / 局所麻酔薬 / 還元物質

Research Abstract

Nucleotide-dependent flavoenzyme (NADPH-p450 reductase) mobilized reductively iron from ferritin. In cultured bovine aortic endothelial cells, lidocaine and procaine, local anesthetics, inhibited the activity of nitric oxide synthase which is one of reducing agents of iron.

Research Products

• [Journal Article] Local anesthetics inhibit nitric oxide production and l-arginine uptake in cultured bovine aortic endothelial cells. (2013)
  • Author(s): Takaishi K, et al.
  • Journal Title: European Journal of Pharmacology Volume: 704 Issue: 1-3 Pages: 58-63
  • DOI: 10.1016/j.ejphar.2013.02.014
  • Peer Reviewed
• [Journal Article] Recent less-invasive circulatory monitoring during renal transplantation (2013)
  • Author(s): Soga T, Kawahito S, Oi R, Kakuta N, Katayama T, Wakamatsu N, Takaishi K,Yamaguchi K, Izaki H, Kanayama H, Kitahata H, Oshita S
  • Journal Title: The Journal of Medical Investigation Volume: 60(1, 2) Pages: 159-163
  • NAID: 120005397334
  • Peer Reviewed
• [Journal Article] Molecular mechanisms of the inhibitory effects of clonidine on vascular adenosine triphosphate-sensitive potassium channels (2011)
  • Author(s): Kawahito S, Kawano T, Kitahata H, Oto J, Takahashi A, Takaishi K, Harada N, Nakagawa T, Kinoshita H, Azuma T, Nakaya Y, Oshita S
  • Journal Title: Anesthesia Analgesia Volume: 113(6) Pages: 1374-1380
  • Peer Reviewed
• [Journal Article] Anaesthesia for a patient with paraneoplastic limbic encephalitis with ovarian teratoma: relationship to anti-N-methyl-D-aspartate receptor antibodies (2011)
  • Author(s): Kawano H, Hamaguchi E, Kawahito S, Tsutsumi YM, Tanaka K, Kitahata H, Oshita S
  • Journal Title: Anaesthesia Volume: 66(6) Pages: 515-518
  • Peer Reviewed
• [Journal Article] Molecular mechanisms of the inhibitory effects of clonidine on vascular adenosine triphosphate-sensitive potassium channels (2011)
  • Author(s): Kawahito S, Kawano T, Kitahata H, Oto J, Takahashi A, Takaishi K, Harada N, Nakagawa T, Kinoshita H, Azma T, Nakaya Y, Oshita S
  • Journal Title: Anesth Analg 2011 Volume: 113 Issue: 6 Pages: 1374-1380
  • DOI: 10.1213/ane.0b013e3182321142
  • Peer Reviewed
• [Presentation] Impact of the newly developed, next-generation artificial dndocrinepancreas (2012)
  • Author(s): Mita N, Kawahito S, Takaishi K, Kitahata H, Oshita S
  • Organizer: American Society of Anesthesiologists,Annual Meeting 2012
  • Place of Presentation: Walter E. Washington Convention Center (the United States of America)
  • Year and Date: 2012-10-16
• [Presentation] The effects of intravenous anesthetics on the release of vascular endothelial growth factor and angiogenesis (2012)
  • Author(s): Takaishi K, Kawahito S, Nakamura D, Tatsuishi T, Eguchi S, Kitahata H:
  • Organizer: Euroanaesthesia
  • Place of Presentation: Palais des Congres de Paris (France).
• [Presentation] The effects of intravenous anesthetics on the release of vascular endothelial growth factor and angiogenesis (2012)
  • Author(s): Takaishi K, et al
  • Organizer: Euroanaesthesia 2012
  • Place of Presentation: Palais des Congres de Paris (France)
• [Book] Contrast Echo Method, Transesophageal echocardiography 2nd edition (2012)
  • Author(s): Kitahata H, Kawahito S
  • Publisher: Shindan-to-Chiryosya, Tokyo