Analysis of T-cell network involved in the pathogenesis and development of oral lichen planus

• Project/Area Number: 23792354
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Surgical dentistry
• Research Institution: Kyushu University
• Principal Investigator: HAYASHIDA Jun-nosuke 九州大学, 歯学研究科(研究院), 助教 (80432920)
• Project Period (FY): 2011 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: サイトカイン / Th1 / Th2 / Th17 / 角化亢進 / 口腔扁平苔癬 / ヘルパーT細胞

Research Abstract

The expression of Th17 type Th1, Th2 was higher in the OLP patientsIn comparison with healthy subjects, but there was no significant difference about Treg type. IL-17 expression was observed in lymphocytes infiltrated under the epithelium, IL-23 was expression in lymphocytes under the epithelium and all hyperkeratic layers. IL-33 was expressed in the basal layer of mucosa.
From these results, expression of Th17 and Th2 is involved in the pathogenesis of OLP addition to Th1, and that it was indicated that hyperkeratosis was caused by the expression of IL-23.

Research Products

• [Journal Article] Differences of Stimulated and Unstimulated Salivary Flow Rates in The Patients with Dry Mouth (2014)
  • Author(s): Jun-Nosuke Hayashida, Sakae Minami, Masafumi Moriyama, Takeshi Toyoshima, Shouichi Shinozaki, Akihiko Tanaka, Takashi Maehara, Seiji Nakamura
  • Journal Title: Journal of Oral and Maxillofacial Surgery, Medicine and Pathology Volume: 27 Issue: 1 Pages: 96-101
  • DOI: 10.1016/j.ajoms.2014.04.011
  • Peer Reviewed / Open Access
• [Journal Article] Differences of Stimulated and Unstimulated Salivary Flow Rates in The Patients with Dry Mouth (2014)
  • Author(s): Jun-Nosuke Hayashida, Sakae Minami, Masafumi Moriyama, Takeshi Toyoshima, Shouichi Shinozaki, Akihiko Tanaka, Takashi Maehara, and Seiji Nakamura
  • Journal Title: Journal of Oral and Maxillofacial Surgery, Medicine and Pathology Volume: 未定
• [Journal Article] Possible involvement of cytokines, chemokines and chemokine receptors in the initiation and progression of chronic GVHD (2013)
  • Author(s): JN, Nakamura S, Toyoshima T, Moriyama M, Sasaki M, Kawamura E, Ohyama Y, Kumamaru W, Shirasuna K.
  • Journal Title: Bone Marrow Transplant. Volume: 48(1) Issue: 1 Pages: 115-23
  • DOI: 10.1038/bmt.2012.100
  • Peer Reviewed
• [Journal Article] Cytokine/chemokine profiles contribute to understanding the pathogenesis and diagnosis of primary Sjögren’s syndrome. (2012)
  • Author(s): Moriyama M
  • Journal Title: Clin Exp Immunol. Volume: 169 Issue: 1 Pages: 17-26
  • DOI: 10.1111/j.1365-2249.2012.04587.x
  • Peer Reviewed
• [Journal Article] Th2 and Regulatory Immune Reactions Contribute to IgG4 Production and the Initiation of Mikulicz Disease (2012)
  • Author(s): Akihiko Tanaka, Masafumi Moriyama, Hitoshi Nakashima, Katsuhisa Miyake, Jun-Nosuke Hayashida, Takashi Maehara, Shouichi Shinozaki, Yoshiaki Kubo, and Seiji Nakamura
  • Journal Title: ARTHRITIS & RHEUMATISM Volume: Vol. 64 Pages: 254-263
• [Journal Article] Cytokine/chemokine profiles contribute to understanding the pathogenesis and diagnosis of primary Sjögren's syndrome
  • Author(s): Moriyama M, Hayashida JN, Toyoshima T, Ohyama Y, Shinozaki S, Tanaka A, Maehara T, Nakamura S
  • Journal Title: Clin Exp Immunol Volume: 169(1) Pages: 17-26
• [Journal Article] Possible involvement of cytokines, chemokines and chemokine receptors in the initiation and progression of chronic GVHD
  • Author(s): Hayashida, J.-N., Nakamura, S., Toyoshima, T., Moriyama, M., Sasaki, M., Kawamura, E., Ohyama, Y., Kumamaru, W., Shirasuna, K
  • Journal Title: Bone Marrow Transplant Volume: 48(1) Pages: 115-123
• [Presentation] 唾液を用いたドライマウスの新しい診断方法および病態把握の試み (2013)
  • Author(s): 大山恵子, 森山雅文, 林田淳之將, 篠崎昌一, 田中昭彦, 前原隆家田晋輔, 古川祥子, 中村誠司
  • Organizer: 第10回日本口腔ケア学会
• [Presentation] 当科過去５年間における扁平苔癬の治療法の検討 (2013)
  • Author(s): 古川祥子、林田淳之將、久保慶朗、豊嶋健史、森山雅文、田中昭彦、前原隆、中村誠司
  • Organizer: 第７９回日本口腔外科学会九州地方会
  • Place of Presentation: 福岡大学メディカルホール
• [Presentation] ミクリッツ病/IgG4関連疾患の臨床的検討 (2012)
  • Author(s): 森山雅文, 林田淳之將 ,田中昭彦, 前原隆, 篠崎昌一, 久保慶朗, 古川祥子, 中村誠司
  • Organizer: 第57回日本口腔外科学会総会
• [Presentation] ビスフォスフォネート製剤を服用したターナー症候群患者に顎矯正手術を施行した 1 例 (2012)
  • Author(s): 古川 祥子，林田淳之將，豊嶋健史，新井伸作，八坂美沙，久保慶朗，北原享，白土雄司，髙橋一郎，中村 誠司
  • Organizer: 第 23 回 日本顎変形症学会総会
  • Place of Presentation: 福岡国際会議場
• [Presentation] 当科過去 5 年間における (2012)
  • Author(s): 古川 祥子,林田 淳之將,久保 慶朗,豊嶋 健史,森山 雅文,田中 昭彦,前原 隆,大山 恵子,家田 晋輔,中村 誠司
  • Organizer: 第 79 回 日本口腔外科学会九州地方会
  • Place of Presentation: 福岡大学メディカルホール
• [Presentation] 当科過去5年間における口腔扁平苔癬の臨床統計的検討 (2011)
  • Author(s): 古川祥子, 林田淳之將, 久保慶朗, 豊嶋健史, 森山雅文, 田中昭彦, 前原隆, 大山恵子, 家田晋輔, 中村誠司
  • Organizer: 日本口腔外科学会九州地方会
  • Place of Presentation: 鹿児島
  • Year and Date: 2011-06-23
• [Presentation] 口腔扁平苔癬の角化亢進における Th17の関与
  • Author(s): 久保慶朗、林田淳之將、 森山雅文、篠崎昌一、田中昭彦、前原隆、大山恵子、家田晋輔、 中村誠司
  • Organizer: 日本口腔粘膜学会
  • Place of Presentation: 鹿児島