Study on the role of dendritic cells in oral squamous cell carcinoma

• Project/Area Number: 23792355
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Surgical dentistry
• Research Institution: Nagasaki University
• Principal Investigator: KAKEHASHI hiroe 長崎大学, 医歯(薬)学総合研究科, 助教 (30452775)
• Project Period (FY): 2011 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: 口腔扁平上皮癌 / 樹状細胞 / 上皮幹細胞 / 口腔白板症 / 癌幹細胞 / 免疫療法 / 幹細胞 / 白板症 / 扁平上皮癌 / タンパク質分解酵素 / カテプシンＥ

Research Abstract

Recent studies have demonstrated that the p75 neurotrophin receptor (p75NTR) is a useful marker of keratinocyte stem cells. Although the stem cell markers of original normal tissue have been used to identify cancer stem cells in a variety of cancers, the expression and function of p75NTR have been poorly understood in oral squamous cell carcinoma (OSCC). The objective of this study is, thus, to examine p75NTR expression immunohistochemically in oral leukoplakia (OL), the most frequent precancerous lesion, and OSCC, and to reveal the usefulness of p75NTR as a marker for undifferentiated cancer cells and a novel prognostic factor for OSCC patients.

Research Products

• [Presentation] 骨祖鬆症に併発したBRONJに対するﾃﾘﾊﾟﾗﾁﾄﾞ治療 (2013)
  • Author(s): 梯 裕恵,吉冨 泉,中谷佑哉,池本啓輔,六反田 賢,川北晃子,池田久住,柳本惣市,梅田正博,朝比奈 泉
  • Organizer: 第58回日本口腔外科学会総会･学術大会
  • Place of Presentation: 福岡福岡国際会議場、マリンメッセ福岡
• [Presentation] BRONJの手術適応について (2013)
  • Author(s): 川北晃子,今山直美,鳴瀬智史,六反田 賢,吉冨 泉,梯 裕恵,山田慎一,柳本惣市,川崎五郎,朝比奈 泉,梅田正博
  • Organizer: 第67回ＮＰＯ法人日本口腔科学会学術集会
  • Place of Presentation: 栃木県総合文化センター
• [Presentation] 粘液嚢胞症例に対するmicro-marsupialization療法の検討 (2013)
  • Author(s): 梯 裕恵,野田さわこ,田島暢崇,白石剛士,住田吉慶,朝比奈 泉
  • Organizer: 第67回ＮＰＯ法人日本口腔科学会学術集会
  • Place of Presentation: 栃木県総合文化センター
• [Presentation] 口腔扁平上皮癌におけるΔNp63の発現と機能 (2010)
  • Author(s): 松原良太, 川野真太郎, 梯裕恵, 中村誠司, ほか
  • Organizer: 第55回日本口腔外科学会総会・学術大会
  • Place of Presentation: 千葉
• [Presentation] Possible involvement ofΔNp63 in proliferation and differentiation of OSCC (2010)
  • Author(s): Ryota MATSUBARA, Shintaro KAWANO, Hiroe KAKEHASHI, Seiji NAKAMURA, et al
  • Organizer: 10^<th> Congress of the European Association of Oral Medicine incorporating the World Workshop on Oral Medicine
  • Place of Presentation: London, England
• [Presentation] Immunohistochemical localization of p75NTR in oral leukoplakia and OSCC (2010)
  • Author(s): Takahiro KIYOSUE, Shintaro KAWANO, Hiroe KAKEHASHI, Seiji NAKAMURA, et al
  • Organizer: 10^<th> Congress of the European Association of Oral Medicine incorporating the World Workshop on Oral Medicine
  • Place of Presentation: London, England
• [Presentation] 口腔扁平上皮癌におけるΔNp63の発現と機能 (2010)
  • Author(s): 松原良太, 川野真太郎, 梯裕恵, 中村誠司, ほか
  • Organizer: 第64回日本口腔科学会総会・学術大会
  • Place of Presentation: 北海道
• [Presentation] 口腔扁平上皮癌における上皮幹細胞マーカー(p63、p75NTR)に関する研究 (2009)
  • Author(s): 松原良太, 川野真太郎, 梯裕恵, 中村誠司, ほか
  • Organizer: 第54回日本口腔外科学会総会・学術大会
  • Place of Presentation: 北海道
• [Presentation] 舌に発生した腺扁平上皮癌の一例
  • Author(s): 白石 剛士, 梯 裕恵, 柳本 惣市, 梅田 正博, 藤田 修一, 池田 通,朝比奈 泉
  • Organizer: 九州口腔癌研究会
  • Place of Presentation: 福岡県歯科医師会館