Would Cytokeratin be a new prognostic marker of oral squamous cell carcinoma?

• Project/Area Number: 23792356
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Surgical dentistry
• Research Institution: Kyushu University
• Principal Investigator: TOYOSHIMA Takeshi 九州大学, 歯学研究科(研究院), 助教 (20546569)
• Project Period (FY): 2011 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2013: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2011: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
• Keywords: 口腔扁平上皮癌 / サイトケラチン / 分化度 / 扁平上皮癌 / 原発巣 / 血中 / 白板症

Research Abstract

The aim of this study was to verify an correlation between CK positive cells and differentiation of oral squamous cell carcinoma (OSCC) in order to clarify if CK in tumor cell would be a new prognostic marker in patients with OSCC. In 20 patients, blood samples were taken pre/postoperatively and in follow-up periods for this study. The positive cases were 20/20 for CK17, 15/20 for CK19, and 12/20 for CK20. The chronological relative ratios were 1:0.73:0.87 for CK17, 1:1.14:1.36 for CK19, and 1:1.7:1.80 for CK20. Between rich and poor prognostic cases, the relative ratios of postoperative 1 month were 0.69 vs 1.38 for CK17, 1.02 vs 1.82 for CK19, and 5.48 vs 0.09 for CK20. These results indicate that CK17 might be a new prognostic marker of OSCC.

Research Products

• [Journal Article] Apoptotic function of tumor-associated antigen (2014)
  • Author(s): Hideaki Tanaka, Takeshi Toyoshima, Kenzo Sonoda, Ryoji Kitamura, Masaaki Sasaguri, Shintaro Kawano, Ryota Matsubara, Yuichi Goto, Seiji Nakamura
  • Journal Title: RCAS1 in oral squamous cell carcinoma Journal of Translational Medicine Volume: (in print)
• [Journal Article] Association of cytokeratin 17 expression with differentiation in oral squamous cell carcinoma (2012)
  • Author(s): Ryoji Kitamura, Takeshi Toyoshima, Hideaki Tanaka, Shintaro Kawano, Takahiro Kiyosue, Ryota Matsubara, Yuichi Goto, Kazunari Oobu, Seiji Nakamura
  • Journal Title: Journal of Cancer Research and Clinical Oncology Volume: 138(8) Pages: 1299-1310
• [Journal Article] Association of cytokeratin 17 expression with differentiation in oral squamous cell carcinoma. (2012)
  • Author(s): Kitamura R, Toyoshima T, Tanaka H, Kawano S, Kiyosue T, Matsubara R, Goto Y, Hirano M, Oobu K, Nakamura S.
  • Journal Title: J Cancer Res Clin Oncol. Volume: 138 Issue: 8 Pages: 1299-1310
  • DOI: 10.1007/s00432-012-1202-6
  • Peer Reviewed
• [Journal Article] Association of cytokeratin 17 expression with differentiation in oral squamous cell carcinoma. (2012)
  • Author(s): Kitamura R, Toyoshima T, et al.
  • Journal Title: J Cancer Res Clin Oncol. Volume: 1 Pages: 110-120
  • Peer Reviewed
• [Journal Article] In vitro induction of specific CD8(+) T lymphocytes by tumor-associated antigenic peptides in patients with oral squamous cell carcinoma. (2012)
  • Author(s): Toyoshima T, et al.
  • Journal Title: Cancer Lett. Volume: 1 Pages: 50-55
  • Peer Reviewed
• [Presentation] 口腔扁平上皮癌由来細胞株における腫瘍関連抗原RCAS1(receptor-binding caner antigen expressed on SiSo cells)の発現と機能についての検討 (2013)
  • Author(s): 1. 田中秀明，豊嶋健史，園田顕三，北村亮二，川野真太郎，平野充広，神野哲平，中村誠司
  • Organizer: 第 31 回日本口腔腫瘍学会
  • Place of Presentation: 東京