| Project/Area Number |
23792356
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Surgical dentistry
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2013
|
| Project Status |
Completed (Fiscal Year 2013)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2013: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2011: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | 口腔扁平上皮癌 / サイトケラチン / 分化度 / 扁平上皮癌 / 原発巣 / 血中 / 白板症 |
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| Research Abstract |
The aim of this study was to verify an correlation between CK positive cells and differentiation of oral squamous cell carcinoma (OSCC) in order to clarify if CK in tumor cell would be a new prognostic marker in patients with OSCC. In 20 patients, blood samples were taken pre/postoperatively and in follow-up periods for this study. The positive cases were 20/20 for CK17, 15/20 for CK19, and 12/20 for CK20. The chronological relative ratios were 1:0.73:0.87 for CK17, 1:1.14:1.36 for CK19, and 1:1.7:1.80 for CK20. Between rich and poor prognostic cases, the relative ratios of postoperative 1 month were 0.69 vs 1.38 for CK17, 1.02 vs 1.82 for CK19, and 5.48 vs 0.09 for CK20. These results indicate that CK17 might be a new prognostic marker of OSCC.
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