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Bone regeneration by using mononuclear cells derived from peripheral blood with homing factor

Research Project

Project/Area Number 23792361
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Surgical dentistry
Research InstitutionUniversity of Fukui (2012)
Nagasaki University (2011)

Principal Investigator

OHBA Seigo  福井大学, 医学部附属病院, 講師 (80363456)

Project Period (FY) 2011 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
KeywordsPRP / 再生 / MNC / レプチン / 単核細胞 / 骨再生 / ホーミング
Research Abstract

There are certain cells which have multilineage potentials in the mononuclear cells of peripheral blood. These cells with the scaffold(B-TCP) were transplanted on the calvalia of mice as an onlay, resulting in synthesizing new bone formation. The amount of new bone was more than the scaffold without cells. Moreover, the bone induction potency was comparable as the bone marrow-derived mononuclear cells.
The mesenchymal stem cells extracted from the marrow of the femur of mice were cultured. These cells were exposed by missed of leptin and BMP-2, which dose was too low to induce more osteoblastogenesis by solely, and the alkaline phosphatase activity was calculated. Moreover, when the gelatin containing leptin and scaffold (B-TCP) was transplanted to the defect region with a clinical size, created to the calvarial bone of a mouse, induced bone regeneration.

Report

(3 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Research-status Report
  • Research Products

    (9 results)

All 2012 2011

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (7 results)

  • [Journal Article] In vivo comparison of the bone regeneration capacity of human bone marrow concentrates vc2012

    • Author(s)
      Zhong, W, Sumita Y, Ohba S, Kawasaki T, Nagai K, Ma G, Asahina I
    • Journal Title

      Platelet-rich plasma.

      Volume: 7

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] In vivo comparison of the bone regeneration capability of human bone marrow concentrates vs. platelet-rich plasma2012

    • Author(s)
      Zhong W, Sumita Y, Ohba S, Kawasaki T, Nagai K, Ma G, Asahina I
    • Journal Title

      PLoS One

      Volume: 7

    • NAID

      120006985697

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Presentation] 骨形成におけるレプチンとBMP-2の相乗効果の検討2012

    • Author(s)
      本岡菜穂美、大場誠悟、朝比奈泉
    • Organizer
      口腔外科学会総会
    • Place of Presentation
      横浜
    • Year and Date
      2012-10-21
    • Related Report
      2012 Final Research Report
  • [Presentation] Bone regeneration capability of human bone marrow concentrates versus platelet rich plasma2012

    • Author(s)
      Mayumi Umebayashi, Weijian Zhong, Yoshinori Sumita, Seigo Ohba, Kazuhiro Nagai, Izumi Asahina
    • Organizer
      International Society for Stem Cell Research
    • Place of Presentation
      シフィコ横浜
    • Year and Date
      2012-06-16
    • Related Report
      2012 Final Research Report
  • [Presentation] 骨再生における骨髄濃縮液と抹消血PRPの有効性の比較検討2012

    • Author(s)
      梅林真由美、仲維剣、住田吉慶、大場誠悟、長井一浩、朝比奈泉
    • Organizer
      再生医療学会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2012-06-14
    • Related Report
      2012 Final Research Report
  • [Presentation] 骨再生における骨髄濃縮液と抹消血PRPの有効性の比較検討2012

    • Author(s)
      梅林真由美、仲維剣、住田吉慶、大場誠悟、長井一浩、朝比奈泉
    • Organizer
      第11回日本再生医療学会総会
    • Place of Presentation
      横浜
    • Related Report
      2012 Annual Research Report
  • [Presentation] Bone regeneration capability of human bone marrow concentrates versus platelet rich plasma2012

    • Author(s)
      Mayumi Umebayashi, Weijian Zhong, Yoshinori Sumita, Seigo Ohba, Kazuhiro Nagai, Izumi Asahina
    • Organizer
      International Society for Stem Cell Research
    • Place of Presentation
      横浜
    • Related Report
      2012 Annual Research Report
  • [Presentation] 骨形成におけるレプチンとBMP-2の相乗効果の検討2012

    • Author(s)
      本岡菜穂美、大場誠悟、朝比奈泉
    • Organizer
      日本口腔外科学会
    • Place of Presentation
      横浜
    • Related Report
      2012 Annual Research Report
  • [Presentation] Bone regeneration capability of human bone-marrow concentrates vs platelet-rich plasma2011

    • Author(s)
      梅林真由美、仲維剣、住田吉慶、大場誠悟、長井一浩、朝比奈泉
    • Organizer
      再生医療研究会
    • Place of Presentation
      長崎
    • Related Report
      2011 Research-status Report

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Published: 2011-08-05   Modified: 2019-07-29  

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