| Project/Area Number |
23792362
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Surgical dentistry
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| Research Institution | Kumamoto University |
|---|
Principal Investigator |
TAKAMUNE Yasuo 熊本大学, 医学部附属病院, 医員 (50467982)
|
|---|
| Project Period (FY) |
2011 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
|
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| Keywords | 細胞接着 / 癌の浸潤・転移 / プロテアーゼ / 口腔癌 / 転移機構 / 接着分子 |
|---|
| Research Abstract |
By converting the mature form of the proform metalloprotease ADAM-17, TNFα revealed that cutting the adhesion molecule CD44, invasion of oral squamous cell carcinoma cells to promote. This time, in view of the adenoid cystic carcinoma is a type of salivary gland cancer, its activity and ADAM-17, was analyzed at the protein level significance of their existence and CD44, but can be found a clear expression did not.
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