| Project/Area Number |
23792363
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Surgical dentistry
|
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| Research Institution | Kumamoto University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 腫瘍免疫 / 口腔癌 / 臨床試験 / ペプチドワクチン療法 / 腫瘍免疫療法 |
|---|
| Research Abstract |
In our department, there are new patients of oral cancer withmore than 80 people a year. No treatment against sever advanced or recurrent cases, sodevelopment of a new treatment is desired. We therefore prepared three of HLA-restrictedpeptides in the target molecule which are expressed specifically in oral cancer tissue,we have administered peptides vaccine to 43 patients in the past. As a result, it waspossible to reject her tumor completely, and to obtain CR in one case. In most cases,the induction of killer T cells recognizing the peptide was confirmed.
In addition, wecan also confirm of their extended both OS and PFS.
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