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Expression analysis of DKK gene and development of a molecular targeted therapy for oral cancer

Research Project

Project/Area Number 23792365
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Surgical dentistry
Research InstitutionSapporo Medical University

Principal Investigator

SOGABE Yohei  札幌医科大学, 医学部, 研究員 (50468104)

Research Collaborator OGI Kazuhiso  札幌医科大学, 医学部, 訪問研究員 (40433114)
HIRATSUKA Hiroyoshi  札幌医科大学, 医学部, 教授 (50165180)
Project Period (FY) 2011 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords臨床腫瘍学 / エピジェネティクス / 癌 / 歯学 / 遺伝子
Research Abstract

In the present study, we examined the relationship between Wnt signaling and epigenetic alteration of the Dickkopf-related protein (DKK) genes in oral squamous cell carcinomas (OSCC). Our result confirms the frequent methylation and silencing of DKK genes in OSCC, and suggest that their loss of function contributes to activation of Wnt signaling that leads to cell proliferation during oral carcinogenesis.

Report

(3 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Research-status Report

URL: 

Published: 2011-08-05   Modified: 2019-07-29  

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