Development of jaw bone reconstruction material made of osteoconductive titanium fiber mesh scaffold.

• Project/Area Number: 23792366
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Surgical dentistry
• Research Institution: Yokohama City University
• Principal Investigator: HIROTA Makoto 横浜市立大学, 医学部, 准教授 (20347305)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2011: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
• Keywords: 口腔顎顔面再建外科学 / 顎骨再建 / チタンファイバースキャホールド / チタンファイバー / ティッシュエンジニアリング

Research Abstract

The aim of this study was evaluation of the bone regeneration properties of titanium fiber scaffold (TFS) that had been coated with a thin hydroxyapatite (HA) layer. Human osteoblasts culture suggested that the HA coated TFS accelerated osteoblast activity. Reconstructive surgery for rabbit mandibular segmental bone defect using titanium fiber block was performed. The discontinuity of the mandibular bone was completely regenerated by newly formed bone in and on the HA/TFS, suggesting TFS is the materials to reconstruct the jaw bone defects.

Research Products

• [Journal Article] Hydroxyapatite coating for titanium fibre mesh scaffold enhances osteoblast activity and bone tissue formation (2012)
  • Author(s): Hirota M, Hayakawa T, Ozawa T 他3名
  • Journal Title: International Journal of Oral and Maxillofacial Surgery Volume: 41 Pages: 1304-1309
  • Peer Reviewed
• [Journal Article] Hydroxyapatite coating for titanium fibre mesh scaffold enhances osteoblast activity and bone tissue formation. (2012)
  • Author(s): Makoto Hirota
  • Journal Title: International Journal of Oral and Maxillofacial Surgery Volume: 41 Pages: 1304-1309
  • Peer Reviewed
• [Journal Article] Hydroxyapatite coating for titanium fibre mesh scaffold enhances osteoblast activity and bone tissue formation. (2012)
  • Author(s): Hirota M, Hayakawa T, Yoshinari M, Ametani A, Shima T, Monden Y, Ozawa T, Sato M, Koyama C, Tamai N, Iwai T, Tohnai I.
  • Journal Title: International Journal of Oral and Maxillofacial Surgery Volume: 26 Pages: 245-250
  • Peer Reviewed
• [Presentation] Development of mandibular reconstruction device made of titanium fiber scaffold (2013)
  • Author(s): Hirota M
  • Organizer: Society for Biomaterials 2013 annual meeting and exposition, Boston
  • Place of Presentation: MA, USA
  • Year and Date: 2013-04-11
• [Presentation] Development of mandibular reconstruction device made of titanium fiber scaffold. (2013)
  • Author(s): Makoto Hirota
  • Organizer: Society for Biomaterials 2013 annual meeting and exposition
  • Place of Presentation: Boston, MA, USA
• [Presentation] Development of mandibular reconstruction device made of titanium fiber scaffold (2012)
  • Author(s): Hirota M
  • Organizer: 3 rd TERMIS World Congress 2012
  • Place of Presentation: Vienna, Austria
  • Year and Date: 2012-09-07
• [Presentation] Development of mandibular reconstruction device made of titanium fiber scaffold. (2012)
  • Author(s): Makoto Hirota
  • Organizer: 3rd TERMIS World Congress 2012
  • Place of Presentation: Vienna, Austria