A study of photodynamic therapy of oral cancer by using Nanofullerenes

• Project/Area Number: 23792373
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Surgical dentistry
• Research Institution: Oita University (2012); Kyushu Dental College (2011)
• Principal Investigator: YAMAMOTO Noriaki 大分大学, 医学部, 助教 (50397923)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 臨床腫瘍学 / ナノフラーレン / 光線陸学療法

Research Abstract

Photodynamic therapy with nano-fullerene was performed in OSCC, but it was considered cytocide by PDT is not enough to only the addition to the medium of nanofullerene, require improvement in the clinical application. Invasion depth PDT of the three-dimensional culture system was slightly shallow, the only administration of the nanofullerenes, it was considered the effect of PDT is inferior when compared with agents such as Photofrin. In order to use nanofullerenes for PDT, it is necessary to improvement of drug.

Research Products

• [Journal Article] Occurrence of silk stitch abscess after surgery in patients with oral squamous cell carcinoma (2013)
  • Author(s): Yamamoto N, Yamashita Y, Yoshiga D, Ishikawa A, Matsuo K,Yamauchi K, Nogami S, Miyamaoto I, Oda M, Tanak T, Kito S, Wakasugi N, Matsumoto S, Seta Y, Takahashi T, Koga H, Kawano K, Morimoto Y
  • Journal Title: Med Oral Patol Oral Cir Bucal
  • Peer Reviewed
• [Journal Article] Solid variant of keratocystic odontogenic tumor of the mandible: Report of a case with a clear cell component and review of the literature (2013)
  • Author(s): Kawano K, Okamura K, Kashima K, Matsuo K, Takahashi Y, Yamamoto N,Kono T, Kawamura K
  • Journal Title: OOOOE
  • Peer Reviewed
• [Journal Article] 肺転移巣からG-CSF 産生を認めた下顎歯肉扁平上皮癌の 1 例 (2013)
  • Author(s): 山本哲彰、〓岡祥子、山内健介、石川文隆、阿部史佳、山下善弘、河野辰行、河野憲司、高橋 哲
  • Journal Title: 口腔腫瘍 Volume: 25 Pages: 13-19
  • NAID: 130003378722
  • Peer Reviewed
• [Journal Article] Occurrence of silk stitch abscess after surgery in patients with oral squamous cell carcinoma (2013)
  • Author(s): Yamamoto N, Yamashita Y, Yoshiga D, Ishikawa A, Matsuo K, Miyamoto I, Oda M, Tanaka T, Kito S, Seta Y, Takahashi T, Koga H, Kenji K, Morimoto Y
  • Journal Title: Med Oral Patol Oral Cir Bucal Volume: 18 Pages: e701-e705
  • DOI: 10.4317/medoral.18792
  • Peer Reviewed
• [Journal Article] 肺転移巣からG-CSF産生を認めた下顎歯肉扁平上皮癌の1例． (2013)
  • Author(s): 山本哲彰
  • Journal Title: 口腔腫瘍 Volume: 25 Pages: 13-19
  • NAID: 130003378722
  • Peer Reviewed
• [Journal Article] 口腔悪性腫瘍診断における18F-FDG-PET/CT の有用性に関する検討 (2012)
  • Author(s): 山本哲彰、山内健介、山下善弘、吉賀大午、宮本郁也、野上晋之介、鬼頭慎司、河野辰行、河野憲司、古賀博文、森本泰宏、高橋 哲
  • Journal Title: 九州歯会誌 Volume: 66 Pages: 104-109
  • NAID: 10031126310
  • Peer Reviewed
• [Journal Article] Risk factors for neurosensory disturbance after a bilateral sagittal split osteotomy based on the position of the mandibular canal and morphology of the mandibular angle (2012)
  • Author(s): Yamauchi K, Takahashi T, Kaneuji T, Nogami S, Yamamoto N, Miyamoto I, Yamashita Y
  • Journal Title: J Oral Maxillofa Surg Volume: 70 Pages: 401-406
  • Peer Reviewed
• [Journal Article] Clinical comparison between the retromandibular approach for reduction andfixation and endoscope-assisted open reduction and internal fixation formandibular condyle fractures (2012)
  • Author(s): Nogami S, Takahashi T, Yamauchi K, Miyamoto I, Kaneuji T, Yamamoto N,Yoshiga D, Yamashita Y
  • Journal Title: Journal of Craniofacial Surgery Volume: 23(6) Pages: 1815-1818
  • Peer Reviewed
• [Journal Article] Reflection of 18F-FDG accumulation in the evaluation of the extent of periapical or periodontal inflammation (2012)
  • Author(s): Kito S, Koga H, Kodama M, Yamamoto N, Kokuryo S, Habu M, Matsuo K, Nishino T, Kubota K, Muraoka M, Oda M, Wakasugi N, Matsumoto S, Seta Y, Tanaka T, Miyamoto I, Yamashita Y, Kitamura C, Nakashima K, Takahashi T, Tominaga K, Morimoto Y
  • Journal Title: OOOE Volume: 114 Pages: 62-69
  • Peer Reviewed
• [Journal Article] 口腔悪性腫瘍診断における18F-FDG-PET/CTの有用性に関する検討． (2012)
  • Author(s): 山本哲彰
  • Journal Title: 九州歯会誌 Volume: 66 Pages: 104-109
  • NAID: 10031126310
  • Peer Reviewed
• [Journal Article] Risk factors for neurosensory disturbance after a bilateral sagittal split osteotomy based on the position of the mandibular canal and morphology of the mandibular angle (2012)
  • Author(s): Yamauchi K, Takahashi T, Kaneuji T, Nogami S, Yamamoto N, Miyamoto I , Yamashita Y
  • Journal Title: Journal of Oral and Maxillofacial Surgery Volume: 70 Pages: 401-406
  • Peer Reviewed
• [Journal Article] Diagnostic significance of characteristic findings on ultrasonography for the stitch abscess after surgery in patients with oral squamous cell carcinoma (2011)
  • Author(s): Yamamoto N, et al.,
  • Journal Title: Oral Oncology Volume: 47 Pages: 163-169
  • Peer Reviewed
• [Journal Article] Prognostic significance of CD44v3 and CD44v6 in oral squamous cell carcinoma of the tongue (2011)
  • Author(s): Shoko Tsuruoka, Kou Matsuo, Ayataka Ishikawa, NoriakiYamamoto, Yoshihiro Yamashita, Tetsu Takahashi
  • Journal Title: Oral Med Pathol Volume: 15 Pages: 107-112
  • NAID: 130004509551
  • Peer Reviewed
• [Journal Article] 顎関節下関節腔に生じた偽痛風の1例 (2011)
  • Author(s): 山本哲彰 他
  • Journal Title: 日本口腔外科学会雑誌 Volume: 57 Pages: 601-605
  • NAID: 10030273094
  • Peer Reviewed
• [Presentation] 当科におけるエナメル上皮腫に対する開窓療法の効果の検討 (2013)
  • Author(s): 吉川宣近、河野辰行、高橋喜浩、山本哲彰、田嶋理江、河野憲司
  • Organizer: 日本口腔腫瘍学会総会
  • Place of Presentation: 一般、東京
• [Presentation] 口腔扁平上皮癌における対側頸部リンパ節転移の検討 (2013)
  • Author(s): 阿部史佳、山本哲彰、高橋喜浩、河野辰行、手島理絵、河野憲司
  • Organizer: 日本口腔腫瘍学会総会
  • Place of Presentation: 一般、東京
• [Presentation] 顎関節に生じた偽痛風の 1 例 (2012)
  • Author(s): 吉賀大午、石川文隆、宮本郁也、山内健介、山本哲彰、野上晋之介、金氏 毅、三次 翔、高橋 哲
  • Organizer: 日本口腔外科学会総会
  • Place of Presentation: 一般、横浜
• [Presentation] 口腔扁平上皮癌の後発転移リンパ節の増大パターンと病理組織学的所見の比較検討 (2012)
  • Author(s): 河野辰行、高橋喜浩、山本哲彰、板井 健、阿部史佳、吉岡俊一、川村和弘、渡邊啓次郎、河野憲司
  • Organizer: 日本口腔外科学会総会
  • Place of Presentation: 一般、横浜
• [Presentation] 化膿性顎関節炎から波及したと思われる頬部蜂窩織炎の一例 (2012)
  • Author(s): 山本哲彰、野上晋之介、山内健介、金氏 毅、吉賀大午、宮本郁也、高橋 哲
  • Organizer: 日本口腔科学会
  • Place of Presentation: 一般、広島
• [Presentation] 術後経過観察中に異物肉芽腫を生じた口腔悪性腫瘍患者における臨床的検討 (2012)
  • Author(s): 山本哲彰、山下善弘、山内健介、宮本郁也、河野辰行、高橋喜浩、河野憲司、高橋 哲
  • Organizer: 日本癌学会
  • Place of Presentation: 一般、横浜
• [Presentation] 術後経過観察中に異物肉芽腫を生じた口腔悪性腫瘍患者における臨床的検討． (2012)
  • Author(s): 山本哲彰
  • Organizer: 日本癌学会
  • Place of Presentation: 横浜
• [Presentation] 化膿性顎関節炎から波及したと思われる頬部蜂窩織炎の一例． (2012)
  • Author(s): 山本哲彰
  • Organizer: 日本口腔科学会
  • Place of Presentation: 広島
• [Presentation] 口腔扁平上皮癌における上皮間葉転換関連因子発現の免疫組織化学的解析 (2012)
  • Author(s): 鶴岡祥子, 石川文隆, 山本哲彰, 山下善弘, 松尾 拡, 高橋 哲
  • Organizer: 日本口腔腫瘍学会
  • Place of Presentation: 大宮ソニックシティー
• [Presentation] 舌下腺原発粘表皮癌の2例 (2012)
  • Author(s): 山本哲彰，石川文隆，鶴岡祥子,野上晋之介，山内健介，宮本郁也，吉賀大午，山下善弘，高橋 哲
  • Organizer: 日本口腔腫瘍学会
  • Place of Presentation: 大宮ソニックシティー
• [Presentation] 舌粘表皮癌と下顎歯肉扁平上皮癌が同時多発性にみられた1例 (2011)
  • Author(s): 山本哲彰, 石川文隆, 山下善弘, 山内健介, 宮本郁也, 高橋 哲
  • Organizer: 日本口腔外科学会総会
  • Place of Presentation: 大阪国際会議場
• [Presentation] ビスフォスフォネート関連顎骨壊死(BRONJ)に関する臨床的検討 (2011)
  • Author(s): 吉賀大午, 山本哲彰, 田中謙光, 金氏毅, 宮本郁也, 野上晋之介, 山内健介, 山下善弘, 高橋 哲
  • Organizer: 日本口腔外科学会総会
  • Place of Presentation: 大阪国際会議場
• [Book] Application of CT for the Study of Pathology of the Jaws (2011)
  • Author(s): Tatsurou Tanaka, Yasuhiro Morimoto, Tatsurou Tanaka, Shinji Kito, Ayataka Ishikawa, Shinya Kokuryo, Noriaki Yamamoto, et al.,
  • Total Pages: 22
  • Publisher: INTECH