The elucidation of the molecular mechanisms of the orofacial neuropathicpain and its treatment strategy
| Project/Area Number |
23792374
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Surgical dentistry
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| Research Institution | Kyushu Dental College |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | 神経障害性疼痛 |
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| Research Abstract |
Orofacial neuropathicpain is sometimes results in deterioration of the quality of life in the patients and the disease accompanies with depression. However, the treatment for the disease has not been established.
In this study the neuropathic pain is resulted from the excessive activation of glutamatergic synaptic transmission and involved with reduction of secretion brain-derived neurotrophic factor (BDNF). The administration BDNF inducer ameliorates the pain and depression in neuropathicpain.
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Report
(4 results)
Research Products
(23 results)
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[Journal Article] Endothelin receptor-mediated responses in trigeminal ganglion neurons2013
Author(s)
Yamamoto T, Ono K, Hitomi S, Harano N, Sago T, Yoshida M, Nunomaki M, Shiiba S, Watanabe S, Nakanishi O, Inenaga K
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Journal Title
J Dent Res
Volume: 92(4)
Pages: 335-339
Related Report
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[Journal Article] Endothelin Receptor-mediated Responses in Trigeminal Ganglion Neurons2013
Author(s)
Yamamoto M, Ono K, Hitomi S, Harano N, Sago T, Yoshida M, Nunomaki M, Shiiba S, Watanabe S, Nakanishi O, Inenaga K.
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Journal Title
J Dental Res
Volume: 92
Issue: 4
Pages: 335-339
DOI
Related Report
Peer Reviewed
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[Journal Article] Distinct time courses of microglial and astrocytic hyperactivation and the glial contribution to pain hypersensitivity in a facial cancer model2012
Author(s)
Sago T, Ono K, Harano N, Furuta-Hidaka K, Hitomi S, Nunomaki M, Yoshida M, Shiiba S, Nakanishi O, Matsuo K, Inenaga K
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Journal Title
Brain Res
Volume: May 31 ; 1457
Pages: 70-80
Related Report
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[Journal Article] Distinct time courses of microglial and astrocytic hyperactivation and the glial contribution to pain hypersensitivity in a facial cancer model2012
Author(s)
Sago T, Ono K, Harano N, Furuta-Hidaka K, Hitomi S, Nunomaki M, Yoshida M, Shiiba S, Nakanishi O, Matsuo K, Inenaga K.
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Journal Title
Brain Research
Volume: 31
Pages: 70-80
Related Report
Peer Reviewed
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[Journal Article] 新しく開発した家庭用磁気刺激装置の肩こりに対する効果2011
Author(s)
山本悟, 西光晴, 佐々木宏典, 石川浩三, 安田聖子, 澄川泰弘, 岸下裕輔, 井田唯香, 吉田充広, 掛田崇寛, 石川敏三
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Journal Title
PAIN RESEARCH
Volume: 26(4)
Pages: 215-221
NAID
Related Report
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[Presentation] 4-Methylcathechol, neurotrophic factor inducer, prevents abnormal pain-emotion response including hypersensitization and mood disorder in rats with chronic pain2012
Author(s)
M. YOSHIDA, S. YASUDA, S. MINODA, K. ISHIKAWA, S. YAMAMOTO, Y. KISHISHITA, S. WATANABE, O. NAKANISHI, T. ISHIKAWA
Organizer
Society for Neuroscience
Place of Presentation
New Orleans, USA
Related Report
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[Presentation] 4-Methylcathechol, neurotrophic factor inducer, prevents abnormal pain-emotion response including hypersensitization and mood disorder in rats with chronic pain2012
Author(s)
M. YOSHIDA, S. YASUDA, S. MINODA, K. ISHIKAWA, S. YAMAMOTO, Y. KISHISHITA, S. WATANABE, O. NAKANISHI, T. ISHIKAWA
Organizer
Society for Neuroscience
Place of Presentation
New Orleans
Related Report
