The elucidation of the molecular mechanisms of the orofacial neuropathicpain and its treatment strategy

• Project/Area Number: 23792374
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Surgical dentistry
• Research Institution: Kyushu Dental College
• Principal Investigator: YOSHIDA Mitsuhiro 九州歯科大学, 歯学部, 助教 (40364153)
• Project Period (FY): 2011 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000); Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
• Keywords: 神経障害性疼痛

Research Abstract

Orofacial neuropathicpain is sometimes results in deterioration of the quality of life in the patients and the disease accompanies with depression. However, the treatment for the disease has not been established.
In this study the neuropathic pain is resulted from the excessive activation of glutamatergic synaptic transmission and involved with reduction of secretion brain-derived neurotrophic factor (BDNF). The administration BDNF inducer ameliorates the pain and depression in neuropathicpain.

Research Products

• [Journal Article] Activation of Different Signals Identified with Glia Cells Contribute to the Progression of Hyperalgesia (2013)
  • Author(s): Satoru Yamamoto, Yusuke Kishishita, Mitsuhiro Yoshida, Daisuke Miura, Hidenori Suzuki, Kozo Ishikawa, Hirofumi Miyazaki, Junzo Nojima, Misa Yamamoto, Toshizo Ishikawa
  • Journal Title: Cell Mol Neurobiol Volume: 33 Pages: 167-174
• [Journal Article] Endothelin receptor-mediated responses in trigeminal ganglion neurons (2013)
  • Author(s): Yamamoto T, Ono K, Hitomi S, Harano N, Sago T, Yoshida M, Nunomaki M, Shiiba S, Watanabe S, Nakanishi O, Inenaga K
  • Journal Title: J Dent Res Volume: 92(4) Pages: 335-339
• [Journal Article] Activation of Different Signals Identified with Glia Cells Contribute to the Progression of Hyperalgesia (2013)
  • Author(s): Satoru Yamamoto; Yusuke Kishishita; Mitsuhiro Yoshida ;Daisuke Miura; Hidenori Suzuki; Kozo Ishikawa; Hirofumi Miyazaki ;Junzo Nojima ; Misa Yamamoto; Toshizo Ishikawa
  • Journal Title: Cellular and Molecular Neurobiology Volume: 33 Issue: 2 Pages: 167-174
  • DOI: 10.1007/s10571-012-9881-8
  • Peer Reviewed
• [Journal Article] Endothelin Receptor-mediated Responses in Trigeminal Ganglion Neurons (2013)
  • Author(s): Yamamoto M, Ono K, Hitomi S, Harano N, Sago T, Yoshida M, Nunomaki M, Shiiba S, Watanabe S, Nakanishi O, Inenaga K.
  • Journal Title: J Dental Res Volume: 92 Issue: 4 Pages: 335-339
  • DOI: 10.1177/0022034513478428
  • Peer Reviewed
• [Journal Article] ラット神経障害性疼痛に対する脊髄4-Methylcatechol投与の効果 (2012)
  • Author(s): 松本吉洋, 椎葉俊司, 福原佳世子, 安田聖子, 石川浩三, 吉田充広, 仲西修, 石川敏三
  • Journal Title: 日本歯科麻酔学会雑誌 Volume: 40(1) Pages: 7-14
• [Journal Article] Distinct time courses of microglial and astrocytic hyperactivation and the glial contribution to pain hypersensitivity in a facial cancer model (2012)
  • Author(s): Sago T, Ono K, Harano N, Furuta-Hidaka K, Hitomi S, Nunomaki M, Yoshida M, Shiiba S, Nakanishi O, Matsuo K, Inenaga K
  • Journal Title: Brain Res Volume: May 31 ; 1457 Pages: 70-80
• [Journal Article] Distinct time courses of microglial and astrocytic hyperactivation and the glial contribution to pain hypersensitivity in a facial cancer model (2012)
  • Author(s): Sago T, Ono K, Harano N, Furuta-Hidaka K, Hitomi S, Nunomaki M, Yoshida M, Shiiba S, Nakanishi O, Matsuo K, Inenaga K.
  • Journal Title: Brain Research Volume: 31 Pages: 70-80
  • Peer Reviewed
• [Journal Article] ラット神経障害性疼痛に対する脊髄4-Methylcatechol投与の効果 (2012)
  • Author(s): 松本吉洋,椎葉俊司,福原佳世子,安田聖子, 石川浩三,吉田充広,仲西 修,石川敏三
  • Journal Title: 日本歯科麻酔学会雑誌 Volume: 40 Pages: 7-14
  • Peer Reviewed
• [Journal Article] 新しく開発した家庭用磁気刺激装置の肩こりに対する効果 (2011)
  • Author(s): 山本悟, 西光晴, 佐々木宏典, 石川浩三, 安田聖子, 澄川泰弘, 岸下裕輔, 井田唯香, 吉田充広, 掛田崇寛, 石川敏三
  • Journal Title: PAIN RESEARCH Volume: 26(4) Pages: 215-221
  • NAID: 10030473625
• [Journal Article] ラット炎症性疼痛の機構に脊髄神経-グリア相互作用が関与する (2011)
  • Author(s): 山田史子, 椎葉俊司, 吉田充広, 原野望, 布巻昌仁, 仲西修, 石川敏三
  • Journal Title: 九州歯科学会雑誌 Volume: 64(6) Pages: 201-207
  • NAID: 10027947583
• [Journal Article] ラット炎症性疼痛の機構に脊髄神経－グリア相互作用が関与する (2011)
  • Author(s): 山田史子、椎葉俊司、吉田充広、原野望、布巻昌仁、仲西修、石川敏三
  • Journal Title: 九州歯科学会雑誌 Volume: 64 Pages: 201-207
  • NAID: 10027947583
  • Peer Reviewed
• [Presentation] 中枢性アロディニアにおける脊髄神経-glia相互作用 (2013)
  • Author(s): 吉田充広, 三浦大輔, 石川浩三, 渡邉誠之, 海江田令次, 仲西修, 石川敏三
  • Organizer: 日本疼痛学会
  • Place of Presentation: 大宮
• [Presentation] GABA-A受容体阻害(Bicuculline)誘発アロディニアにおける脊髄神経-glia機構 (2013)
  • Author(s): 吉田充広, 石川浩三, 福原佳代子, 安田聖子, 仲西修, 渡邉誠之, 石川敏三
  • Organizer: 日本歯科麻酔学会
  • Place of Presentation: 横浜
• [Presentation] Spinal microglia mediate the modulation in the GABAA receptor antagonist induced allodynia (2013)
  • Author(s): M. YOSHIDA, O. NAKANISHI, K. ISHIKAWA, D. MIURA, H. SASAKI, S. YASUDA, Y. IDA, Y. IWANAGA, S. WATANABE, T. ISHIKAWA
  • Organizer: Society for Neuroscience
• [Presentation] 中枢性アロディニアにおける脊髄神経-glia相互作用 (2013)
  • Author(s): 吉田充広、三浦大輔、石川浩三、渡邉誠之、海江田令次、仲西 修、 石川敏三
  • Organizer: 日本疼痛学会
  • Place of Presentation: 埼玉県大宮市
• [Presentation] GABA-A受容体阻害（Bicuculline）誘発アロディニアにおける脊髄神経-glia機構 (2013)
  • Author(s): 吉田充広、石川浩三、福原佳代子、安田聖子、仲西修、渡邉誠之、石川敏三
  • Organizer: 日本歯科麻酔学会
  • Place of Presentation: 神奈川県横浜市
• [Presentation] 慢性疼痛における痛覚過敏反応の神経薬理学的解析 (2012)
  • Author(s): 吉田充広, 安田聖子, 石川浩三, 岸下裕輔, 掛田崇宏, 有吉亨, 仲西修, 石川敏三
  • Organizer: 慢性疼痛学会
  • Place of Presentation: 東京
• [Presentation] 難治性疼痛にの発症機構の解析 (2012)
  • Author(s): 三浦大輔, 石川浩三, 吉田充広, 海江田令次, 石川歳三
  • Organizer: 慢性疼痛学会
  • Place of Presentation: 東京
• [Presentation] ラット慢性疼痛における痛覚に対する過敏反応の分子機構 : pERK, BDNFの変調 (2012)
  • Author(s): 吉田充広, 安田聖子, 蓑田誠治, 石川浩三, 仲西修, 石川敏三
  • Organizer: 日本疼痛学会
  • Place of Presentation: 熊本
• [Presentation] 慢性疼痛における痛覚過敏反応およびうつ症状の発症機構解析 (2012)
  • Author(s): 吉田充広, 福原佳代子, 安田聖子, 松本吉洋, 仲西修, 石川敏三
  • Organizer: 日本歯科麻酔学会
  • Place of Presentation: 福岡
• [Presentation] 4-Methylcathechol, neurotrophic factor inducer, prevents abnormal pain-emotion response including hypersensitization and mood disorder in rats with chronic pain (2012)
  • Author(s): M. YOSHIDA, S. YASUDA, S. MINODA, K. ISHIKAWA, S. YAMAMOTO, Y. KISHISHITA, S. WATANABE, O. NAKANISHI, T. ISHIKAWA
  • Organizer: Society for Neuroscience
  • Place of Presentation: New Orleans, USA
• [Presentation] ラット慢性疼痛における痛覚に対する過敏反応の分子機構：pERK, BDNFの変調 (2012)
  • Author(s): 吉田充広、安田聖子、蓑田誠治、石川浩三、仲西修、石川敏三
  • Organizer: 日本疼痛学会
  • Place of Presentation: 熊本
• [Presentation] 4-Methylcathechol, neurotrophic factor inducer, prevents abnormal pain-emotion response including hypersensitization and mood disorder in rats with chronic pain (2012)
  • Author(s): M. YOSHIDA, S. YASUDA, S. MINODA, K. ISHIKAWA, S. YAMAMOTO, Y. KISHISHITA, S. WATANABE, O. NAKANISHI, T. ISHIKAWA
  • Organizer: Society for Neuroscience
  • Place of Presentation: New Orleans