Development of a new gene transfer therapy using nanobubbles in temporomandibular jyoint
Project/Area Number |
23792376
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Surgical dentistry
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Research Institution | Kyushu Dental College |
Principal Investigator |
HABU MANABU 九州歯科大学, 歯学部, 助教 (00360058)
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Project Period (FY) |
2011 – 2013
|
Project Status |
Completed (Fiscal Year 2013)
|
Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
|
Keywords | 超音波遺伝子導入 / ナノバブル / 慢性顎関節炎 / 抗サイトカイン療法 / アポトーシス / 超音波遺伝子導入法 / 顎関節炎モデル / 顎関節炎モデル |
Research Abstract |
Chronic inflammation in the temporomandibular joint alters bone and cartilage, which gives patients long term pain and trismus. Only symptomatic treatments are currently available for this dysfunction. We aim to establish a method for long term reduction in inflammation, by directly delivering a gene which produces an inflammation reducing protein in the temporomandibular joint. In this study, we investigated the possibility of a therapeutic gene application for temporomandibular joint tissues. As the method, the gene is placed in a nano-bubble, a very small shell, and then ultrasound is applied in order for efficient gene delivery to the tissues. The results show a sufficient amount of gene delivery for treatment. We plan to evaluate the effect of the method by testing in animals.
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Report
(4 results)
Research Products
(10 results)
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[Journal Article] Effect of bone quality and position of the inferior alveolar nerve canal in continuous, long-term, neurosensory disturbance after sagittal split ramus osteotomy.2012
Author(s)
Yoshioka,I.,Tanaka,T.,Habu,M.,Oda,M.,Kodama,M.,Kito,S.,Seta,Y.,Tominaga,K.,Sakoda,S.and Morimoto Y.
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Journal Title
J Craniomaxillofac Surg.
Volume: 40
Pages: 178-83
Related Report
Peer Reviewed
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[Journal Article] Local effects of intra-articular injection of anti-rabbit tumor necrosis factor alpha monoclonal antibody in antigen-induced arthritis of the rabbit temporomandibular joit2011
Author(s)
Ohtani,T.,Habu,M., khanal,A., Yoshioka,I.,Matsukawa, A.Tominaga,K.
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Journal Title
J Oral Pathol Med
Volume: 41
Pages: 96-105
Related Report
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[Journal Article] Local effects of intra-articular injection of anti-rabbit tumor necrosis factor alpha monoclonal antibody in antigen-induced arthritis of the rabbit temporomandibular joit.2011
Author(s)
Ohtani,T.,Habu,M., khanal,A., Yoshioka,I.,Matsukawa,A.and Tominaga,K
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Journal Title
J Oral Pathol Med
Volume: 41
Pages: 96-105
Related Report
Peer Reviewed
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