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Development of specific molecular target therapy for intractable disease in the oral and maxillofacial Region using the nanobubble and ultrasound

Research Project

Project/Area Number 23792377
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Surgical dentistry
Research InstitutionKyushu Dental College

Principal Investigator

IWANAGA Kenjiro  九州歯科大学, 歯学部, 助教 (20448484)

Project Period (FY) 2011 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Keywordsソノポレーション / ナノバブル / 遺伝子導入
Research Abstract

Polyethylene glycosylated (PEG) liposome avoids uptake by the reticulo-endothelial system, thus improving drug delivery to tumor while decreasing systemic toxicity. PEGliposomes containing doxorubicin, Doxil, have been used to treat Kaposi's sarcoma and ovarian cancer in clinics. Doxil(R) circulates around the body at a stable state and accumulates in tumor by passive targeting. Although it is difficult to release doxorubicin after accumulation into the tumor, we made new bubble liposomes from Doxi(R) and investigated the effect on cytotoxicity in human gingival squamous cell carcinoma Ca9-22 cells by combination with this new Doxil(R) bubble liposome,encapsulated doxorubicin bubble liposomes (EDBL), and ultrasound. The combination of EDBL and ultrasound was found to enhance the cytotoxity of Ca9-22 cells treated by doxorubicin. This findings suggest that combination of EDBL and ultrasound might be an effective drug delivery system against cancer cells.

Report

(3 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Research-status Report
  • Research Products

    (24 results)

All 2013 2012 2011 Other

All Journal Article (11 results) (of which Peer Reviewed: 8 results) Presentation (13 results)

  • [Journal Article] Mechanisms of G1 cell cycle arrest and apoptosis in myeloma cells induced by hybrid-compound histone deacetylase inhibitor2013

    • Author(s)
      Fujii, S., Okinaga, T., Ariyoshi, W., Takahashi, O., Iwanaga, K., Nishino, N., Tominaga, K., Nishihara, T
    • Journal Title

      iochem Biophys Res Commun

      Volume: 434 Pages: 413-20

    • Related Report
      2012 Final Research Report
  • [Journal Article] Mechanisms of G1 cell cycle arrest and apoptosis in myeloma cells induced by hybrid-compound histone deacetylase inhibitor2013

    • Author(s)
      Fujii, S., Okinaga, T., Ariyoshi, W., Takahashi, O., Iwanaga, K., Nishino, N., Tominaga, K., Nishihara, T
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 434 Issue: 3 Pages: 413-20

    • DOI

      10.1016/j.bbrc.2013.03.043

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 上顎骨中心性に発生したと考えられた粘表皮癌の1例2013

    • Author(s)
      岩永賢二郎・馬杉亮彦・山下善弘・石川文隆・松尾 拡・冨永和宏
    • Journal Title

      日本口腔外科学会雑誌

      Volume: 59 Pages: 177-181

    • NAID

      40019635394

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 抜歯後疼痛に対するJNS013(トラマドール塩酸塩/アセトアミノフェン配合錠)の臨床評価 各配合成分の単独投与との二重盲検比較試験2012

    • Author(s)
      新谷 悟,小村 健, 久保田 英朗, 金子 明寛, 覚道 健治, 山下 徹郎, 中嶋 頼俊, 今井 裕, 伊能 智明, 山本 英雄, 渡貫 圭, 平木 昭光, 岩永 賢二郎, 神部 芳則, 坂田 秀雄
    • Journal Title

      日本口腔外科学会雑誌

      Volume: 58 Pages: 110-122

    • NAID

      10031144868

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Ariyoshi,W.,Tominaga,K. Nishino,N and Nishihara,T:Novelhistone deacetylase inhibitor exhibits antitumor activity via apoptosis induction in oral squamous cell carcinoma2011

    • Author(s)
      Takahashi,O.,Okinaga,T.,Iwanaga,K., Habu,M
    • Journal Title

      Journal of Biophysical Chemistry

      Volume: 2 Pages: 215-221

    • Related Report
      2012 Final Research Report
  • [Journal Article] 2011. Inhibition of adjuvant arthritis in rats2011

    • Author(s)
      Sukedai,M., Ariyoshi, W., Okinaga, T, K. Iwanaga, M. Habu, I. Yoshioka, K. Tominaga, T. Nishihara
    • Journal Title

      electroporation with interleukin-1 receptor antagonist. J. Interferon and Cytokine Res

      Volume: 31 Pages: 839-46

    • Related Report
      2012 Final Research Report
  • [Journal Article] Mechanism involved in enhancement of osteoblast differentiation by hyaluronic acid.2011

    • Author(s)
      Kawano M, Ariyoshi W, Iwanaga K, Okinaga T, Habu M, Yoshioka I, Tominaga K, Nishihara T.
    • Journal Title

      Biochem Biophys Res Commun.

      Volume: 405 Pages: 575-80

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Inhibition of adjuvant arthritis in rats by electroporation with interleukin-1 receptor antagonist2011

    • Author(s)
      Sukedai M, Ariyoshi W, Okinaga T, Iwanaga K, Habu M, Yoshioka I, Tominaga K, Nishihara T
    • Journal Title

      Journal of Interferon & Cytokine Research

      Volume: 31(11) Issue: 11 Pages: 839-846

    • DOI

      10.1089/jir.2011.0024

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Role of heme oxygenase-1 in inframmatory response induced by mechanical stretch in synovial cells2011

    • Author(s)
      Takao,M., Okinaga,T., Ariyoshi,W., Iwanaga,K., Nakamichi,I., Yoshioka,I., Tominaga,K. and Nishihara,T
    • Journal Title

      Inflamm Res

      Volume: 60 Pages: 861-7

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Novel histone deacetylase inhibitor exhibits antitumor activity via apoptosis induction in oral squamous cell carcinoma2011

    • Author(s)
      Takahashi,O.,Okinaga,T.,Iwanaga,K., Habu,M., Ariyoshi,W.,Tominaga,K. Nishino,N and Nishihara,T
    • Journal Title

      Journal of Biophysical Chemistry

      Volume: 2 Pages: 215-221

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] A novel modification in combined Le Fort I and horseshoe osteotomy for posterior repositioning of the maxilla2011

    • Author(s)
      Yoshioka,I.,Amit Khanal.,Kodama, M.,Habu,M., Nishikawa,T.,Iwanaga, K., Kokuryo, S., Basugi, A.,Sakoda, S.,Fukuda, J.and Tominaga,K.
    • Journal Title

      Asian Journal of Oral and Maxillofacial Surgery

      Volume: 23 Pages: 172-176

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Presentation] 冨永和宏.ナノ・マイクロバブルと超音波を利用したドラッグデリバリーシステムの確立2013

    • Author(s)
      岩永賢二郎,沖永敏則,山本雅史,西原達次
    • Organizer
      第73回九州歯科学会総会
    • Place of Presentation
      北九州
    • Year and Date
      2013-05-19
    • Related Report
      2012 Final Research Report
  • [Presentation] ナノバブルを利用した超音波遺伝子・ドラッグデリバリーシステムの確立2012

    • Author(s)
      岩永賢二郎
    • Organizer
      第72回九州歯科学会総会
    • Place of Presentation
      北九州
    • Year and Date
      2012-05-18
    • Related Report
      2012 Annual Research Report 2012 Final Research Report
  • [Presentation] 骨肉腫細胞系に対する新規ヒストン脱アセチル化酵素阻害剤の抗腫瘍効果2011

    • Author(s)
      高橋理 高久治之 岩永賢二郎 土生学 福田仁一
    • Organizer
      第65回日本口腔科学会総会
    • Place of Presentation
      東京
    • Related Report
      2011 Research-status Report
  • [Presentation] 結核性リンパ節炎との鑑別に苦慮した頸部蜂窩織炎の1 例2011

    • Author(s)
      西川健 國領真也 土生学 兒玉正明 岩永賢二郎 福田仁一
    • Organizer
      第65回日本口腔科学会総会
    • Place of Presentation
      東京
    • Related Report
      2011 Research-status Report
  • [Presentation] ヒストン脱アセチル化酵素阻害剤はマウスミエローマ細胞における細胞周期の停止を誘導する2011

    • Author(s)
      藤井誠子 高橋理 岩永賢二郎 土生学 福田仁一 冨永和宏
    • Organizer
      第65回日本口腔科学会総会
    • Place of Presentation
      東京
    • Related Report
      2011 Research-status Report
  • [Presentation] 骨肉腫細胞系における新規ヒストン脱アセチル化酵素阻害剤に対する感受性の違い2011

    • Author(s)
      高久治之,高橋理,沖永敏則,岩永賢二郎,有吉渉,冨永和宏,西原達次.
    • Organizer
      第71回九州歯科学会総会
    • Place of Presentation
      北九州
    • Related Report
      2011 Research-status Report
  • [Presentation] ミエローマ細胞におけるヒストン脱アセチル化酵素阻害剤の影響2011

    • Author(s)
      藤井誠子,沖永敏則,有吉渉,高橋理,岩永賢二郎,土生学,冨永和宏,西原達次.
    • Organizer
      第71回九州歯科学会総会
    • Place of Presentation
      北九州
    • Related Report
      2011 Research-status Report
  • [Presentation] 新規ヒストン脱アセチル化酸素阻害剤が誘導するミエローマ細胞における細胞周期停止機構の解析2011

    • Author(s)
      藤井誠子 沖永敏則 有吉渉 高橋理 岩永賢二郎 土生学 冨永和宏 西原達次
    • Organizer
      第53回日本歯科基礎医学会総会
    • Place of Presentation
      岐阜
    • Related Report
      2011 Research-status Report
  • [Presentation] マウスミエローマ細胞株における新規ヒストン脱アセチル化阻害剤に対する感受性の違い

    • Author(s)
      藤井誠子 高橋理 岩永賢二郎 土生学 福田仁一 冨永和宏
    • Organizer
      第66回日本口腔科学会総会
    • Place of Presentation
      広島
    • Related Report
      2012 Annual Research Report
  • [Presentation] 当科における新来患者の臨床統計学的観察

    • Author(s)
      金子純也國領真也土生学馬杉亮彦岩永賢二郎兒玉正明西川健高橋,山中雅,鶴島弘,藤井誠,森久美子坂口修柳田優介田中純平谷口広祐福田達也安藤有美早川真奈山本雅史原口和也福田仁一冨永和宏
    • Organizer
      第72回九州歯科学会総会
    • Place of Presentation
      北九州
    • Related Report
      2012 Annual Research Report
  • [Presentation] オトガイ後退を伴う上顎過成長に対する馬蹄型骨切りを併用した上顎単独骨切り術

    • Author(s)
      冨永和宏 土生学 馬杉亮彦 岩永賢二郎 兒玉正明 福田仁一
    • Organizer
      第22回日本顎変形症学会
    • Place of Presentation
      福岡
    • Related Report
      2012 Annual Research Report
  • [Presentation] 口外法にて手術した茎状突起過長症の1例

    • Author(s)
      早川真奈 土生学 谷口広祐 岩永賢二郎 兒玉正明 國領真也 西川健 福田仁一 冨永和宏
    • Organizer
      第80回日本口腔外科学会九州地方会
    • Place of Presentation
      鹿児島
    • Related Report
      2012 Annual Research Report
  • [Presentation] ミエローマ細胞における新規ヒストン脱アセチル化阻害剤の効果

    • Author(s)
      藤井誠子 高橋理 岩永賢二郎 土生学 福田仁一 冨永和宏
    • Organizer
      第57回日本口腔外科学会総会
    • Place of Presentation
      横浜
    • Related Report
      2012 Annual Research Report

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Published: 2011-08-05   Modified: 2019-07-29  

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