Investigation of a mechanism of HIF2-alpha-related dediffererentiation in oral squamous cell cartinoma
Project/Area Number |
23792383
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Multi-year Fund |
Research Field |
Surgical dentistry
|
Research Institution | Showa University |
Principal Investigator |
|
Project Period (FY) |
2011 – 2012
|
Project Status |
Completed (Fiscal Year 2012)
|
Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
Keywords | Hypoxia / 扁平上皮癌 / 口腔癌 / 低酸素 / 転写因子 / HIF-1 |
Research Abstract |
In the present study, the mechanism of HIF-2 alpha on transformation of oral squamous cell cartinoma cells into cancer stem cells during hypoxia has been investigated, and thereby, HIF-2 alpha have been shown as a molecular target for a novel therapeutic strategy against cancer-stem-cell-like cells.
|
Report
(3 results)
Research Products
(4 results)
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[Journal Article] Anti-tumor activity of dehydroxymethylepoxyquinomicin against human oral squamous cell carcinoma cell lines in vitro and in vivo.2012
Author(s)
Yasuda, A., Kondo, S., Nagumo, T., Tsukamoto, H., Mukudai, Y., Umezawa, K., Shintani, S.
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Journal Title
Oral oncology
Volume: 47
Issue: 5
Pages: 334-9
DOI
Related Report
Peer Reviewed
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[Journal Article] Evaluation of anticancer activities of benzo[c]phenanthridine alkaloid sanguinarine in oral squamous cell carcinoma cell line.2012
Author(s)
Tsukamoto, H., Kondo, S., Mukudai, Y., Nagumo, T., Yasuda, A., Kurihara, Y., Kamatani, T., Shintani, S.
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Journal Title
Anticancer Res
Volume: 31
Pages: 2841-6
Related Report
Peer Reviewed
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[Journal Article] Anti-tumor activity of dehydroxymethylepoxyquinomicin against human oral squamous cell carcinoma cell lines in vitro and in vivo2011
Author(s)
Yasuda, A., Kondo, S., Nagumo, T., Tsukamoto, H., Mukudai, Y., Umezawa, K., Shintani, S
-
Journal Title
Oral oncology
Volume: 47(5)
Related Report
-
[Journal Article] Evaluation of anticancer activities of benzo[c]phenanthridine alkaloid sanguinarine in oral squamous cell carcinoma cell line2011
Author(s)
Tsukamoto, H., Kondo, S., Mukudai, Y., Nagumo, T., Yasuda, A., Kurihara, Y., Kamatani, T., Shintani, S
-
Journal Title
Anticancer Res
Volume: 31(9)
Related Report