Investigation of a mechanism of HIF2-alpha-related dediffererentiation in oral squamous cell cartinoma

• Project/Area Number: 23792383
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Surgical dentistry
• Research Institution: Showa University
• Principal Investigator: NAGUMO Tatsuhito 昭和大学, 歯学部, 助教 (70555078)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: Hypoxia / 扁平上皮癌 / 口腔癌 / 低酸素 / 転写因子 / HIF-1

Research Abstract

In the present study, the mechanism of HIF-2 alpha on transformation of oral squamous cell cartinoma cells into cancer stem cells during hypoxia has been investigated, and thereby, HIF-2 alpha have been shown as a molecular target for a novel therapeutic strategy against cancer-stem-cell-like cells.

Research Products

• [Journal Article] Anti-tumor activity of dehydroxymethylepoxyquinomicin against human oral squamous cell carcinoma cell lines in vitro and in vivo. (2012)
  • Author(s): Yasuda, A., Kondo, S., Nagumo, T., Tsukamoto, H., Mukudai, Y., Umezawa, K., Shintani, S.
  • Journal Title: Oral oncology Volume: 47 Issue: 5 Pages: 334-9
  • DOI: 10.1016/j.oraloncology.2011.03.001
  • Peer Reviewed
• [Journal Article] Evaluation of anticancer activities of benzo[c]phenanthridine alkaloid sanguinarine in oral squamous cell carcinoma cell line. (2012)
  • Author(s): Tsukamoto, H., Kondo, S., Mukudai, Y., Nagumo, T., Yasuda, A., Kurihara, Y., Kamatani, T., Shintani, S.
  • Journal Title: Anticancer Res Volume: 31 Pages: 2841-6
  • Peer Reviewed
• [Journal Article] Anti-tumor activity of dehydroxymethylepoxyquinomicin against human oral squamous cell carcinoma cell lines in vitro and in vivo (2011)
  • Author(s): Yasuda, A., Kondo, S., Nagumo, T., Tsukamoto, H., Mukudai, Y., Umezawa, K., Shintani, S
  • Journal Title: Oral oncology Volume: 47(5)
• [Journal Article] Evaluation of anticancer activities of benzo[c]phenanthridine alkaloid sanguinarine in oral squamous cell carcinoma cell line (2011)
  • Author(s): Tsukamoto, H., Kondo, S., Mukudai, Y., Nagumo, T., Yasuda, A., Kurihara, Y., Kamatani, T., Shintani, S
  • Journal Title: Anticancer Res Volume: 31(9)