| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Research Abstract |
Dental pulp is an easily obtainable cell-source of viable cells including Schwann and neural progenitor cells for peripheral nerve regeneration. A silicone tube containing rat dental pulp cells was transplanted into a gap of the facial nerve in rats. Tubulation with dental pulp cells could recover facial-nerve defect functionally and electrophysiologically in rats. Moreover, a silicone tube containing miniature pig dental pulp cells was transplanted into a gap of the facial nerve in miniature pigs. However, no nerve regeneration was observed 4 months after surgery. Further investigation was necessary for the peripheral nerve regeneration in miniature pigs.
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