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Regeneration of the peripheral nerve using dental pulp cells

Research Project

Project/Area Number 23792386
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Surgical dentistry
Research InstitutionTokyo Women's Medical University

Principal Investigator

SASAKI Ryo  東京女子医科大学, 医学部, 講師 (60524709)

Project Period (FY) 2011 – 2012
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords神経再生 / 歯髄 / 智歯 / 顔面神経 / 末梢神経再生 / 顔面神経再生
Research Abstract

Dental pulp is an easily obtainable cell-source of viable cells including Schwann and neural progenitor cells for peripheral nerve regeneration. A silicone tube containing rat dental pulp cells was transplanted into a gap of the facial nerve in rats. Tubulation with dental pulp cells could recover facial-nerve defect functionally and electrophysiologically in rats. Moreover, a silicone tube containing miniature pig dental pulp cells was transplanted into a gap of the facial nerve in miniature pigs. However, no nerve regeneration was observed 4 months after surgery. Further investigation was necessary for the peripheral nerve regeneration in miniature pigs.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (22 results)

All 2014 2013 2012 2011 Other

All Journal Article (8 results) (of which Peer Reviewed: 2 results) Presentation (14 results)

  • [Journal Article] Electrophysiological and functional evaluations of regenerated facial-nerve defect with a tube containing dental pulp cells in rats2014

    • Author(s)
      Ryo Sasaki, Hajime Matsumine, Yorikatsu Watanabe, Yuichi Takeuchi, Masayuki Yamato, Teruo Okano, Mariko Miyata, Tomohiro Ando
    • Journal Title

      Plastic and Reconstructive Surgery

      Volume: (in press)

    • Related Report
      2013 Final Research Report
  • [Journal Article] Anesthesia for research on reconstructive facial surgery in rats2013

    • Author(s)
      Ryo Sasaki, Hajime Matsumine, Yorikatsu Watanabe, Masayuki Yamato, Tomohiro Ando
    • Journal Title

      Journal of Reconstructive Microsurgery

      Volume: 29(03) Pages: 209-210

    • Related Report
      2013 Final Research Report
  • [Journal Article] Surgical anatomy of the sural nerve for peripheral nerve reconstruction research in swine2013

    • Author(s)
      Ryo Sasaki, Hajime Matsumine, Yorikatsu Watanabe, Masayuki Yamato, Teruo Okano, Tomohiro Ando
    • Journal Title

      Scandinavian Journal of Laboratory Animal Science

      Volume: (in press)

    • NAID

      120006602911

    • Related Report
      2013 Final Research Report
  • [Journal Article] 歯髄細胞を組み込んだPLGA神経誘導管は顔面神経再生を促進する2013

    • Author(s)
      佐々木亮, 松峯元, 渡辺頼勝
    • Journal Title

      日本口腔外科学会雑誌

      Volume: 59(6) Pages: 404-411

    • NAID

      130004707962

    • Related Report
      2013 Final Research Report
  • [Journal Article] Anesthesia for reconstructive surgical research in rat face2013

    • Author(s)
      Ryo Sasaki, Hajime Matsumine, Yorikatsu Watanabe, Masayuki Yamato, Tomohiro Ando
    • Journal Title

      Journal of Reconstructive Microsurgery

      Volume: 29 Issue: 03 Pages: 209-2010

    • DOI

      10.1055/s-0032-1331147

    • Related Report
      2013 Annual Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Spontaneous fibrosarcoma in an experimental aged Lewis rat2012

    • Author(s)
      Ryo Sasaki, Hajime Matsumine, Naoyuki Matsumoto, Yorikatsu Watanabe, Masayuki Yamato, Teruo Okano, Tomohiro Ando
    • Journal Title

      Laboratory Animals

      Volume: 46 Pages: 352-355

    • Related Report
      2013 Final Research Report 2012 Research-status Report
  • [Journal Article] Punch and spindle-shaped biopsies for collecting oral mucosal tissue for the fabrication of transplantable autologous epithelial cell sheets2012

    • Author(s)
      Ryo Sasaki, Masayuki Yamato, Ryo Takagi, Takashi Ohki, Hajime Matsumine, Teruo Okano, Tomohiro Ando
    • Journal Title

      Journal of Biomedical Materials Research Part A

      Volume: 100 Issue: 10 Pages: 2849-2854

    • DOI

      10.1002/jbm.a.34216

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] PLGA artificial nerve conduits with dental pulp cells promote facial nerve regeneration2011

    • Author(s)
      Ryo Sasaki, Shunsuke Aoki, Masayuki Yamato, Hiroto Uchiyama, Keiji Wada, Hideki Ogiuchi, Teruo Okano, Tomohiro Ando
    • Journal Title

      Journal of Tissue Engineering and Regenerative Medicine

      Volume: 5 Pages: 823-830

    • NAID

      130004707962

    • Related Report
      2013 Final Research Report 2011 Research-status Report
  • [Presentation] 歯髄細胞を組み込んだハイブリッド型神経誘導管によるラット顔面神経再生 : 機能的・電気生理学的検討2014

    • Author(s)
      佐々木亮, 安藤智博
    • Organizer
      第68回NPO法人日本口腔科学会学術集会
    • Related Report
      2013 Final Research Report
  • [Presentation] 歯髄細胞を組み込んだハイブリッド型神経誘導管によるラット顔面神経再生:機能的・電気生理学的検討2014

    • Author(s)
      佐々木亮、安藤智博
    • Organizer
      第68回NPO法人日本口腔科学会学術集会
    • Place of Presentation
      東京
    • Related Report
      2013 Annual Research Report
  • [Presentation] Anesthesia for research on facial reconstructive surgery in rats2013

    • Author(s)
      Ryo Sasaki, Hajime Matsumine, Yorikatsu Watanabe, Masayuki Yamato, Tomohiro Ando
    • Organizer
      21st International Conference on Oral and Maxillofacial Surgery, ICOMS2013
    • Place of Presentation
      Barcelona, Spain
    • Related Report
      2013 Final Research Report
  • [Presentation] Rat facial nerve defect model for facial nerve regeneration study2013

    • Author(s)
      Ryo Sasaki, Yorikatsu Watanabe, Hajime Matsumine, Masayuki Yamato, Sunsuke Aoki, Hiroto Uchiyama, Keiji Wada, Hideki Ogiuchi, Teruo Okano, Tomohiro Ando
    • Organizer
      12th International Facial Nerve Symposium
    • Place of Presentation
      Liberty Hotel, Boston, MA
    • Related Report
      2013 Final Research Report
  • [Presentation] Anesthesia for research on facial reconstructive surgery in rats2013

    • Author(s)
      Ryo Sasaki, Hajime Matsumine, Yorikatsu Watanabe, Masayuki Yamato, Tomohiro Ando
    • Organizer
      21st International Conference on Oral and Maxillofacial Surgery, ICOMS2013
    • Place of Presentation
      バルセロナ、スペイン
    • Related Report
      2013 Annual Research Report
  • [Presentation] Rat facial nerve defect model for facial nerve regeneration study2013

    • Author(s)
      Ryo Sasaki, Yorikatsu Watanabe, Hajime Matsumine, Masayuki Yamato, Shunsuke Aoki, Hiroto Uchiyama, Keiji Wada, Hideki Ogiuchi, Teruo Okano and Tomohiro Ando
    • Organizer
      12th International Facial Nerve Symposium
    • Place of Presentation
      ボストン、アメリカ
    • Related Report
      2013 Annual Research Report
  • [Presentation] 顔面神経再生研究におけるラット顔面神経欠損モデル2012

    • Author(s)
      佐々木亮, 松峯元, 渡辺頼勝
    • Organizer
      第35回日本顔面神経研究会
    • Place of Presentation
      福島県猪苗代
    • Related Report
      2013 Final Research Report
  • [Presentation] Biopsies for collecting oral mucosal tissue for tissue for tissue-engineered cell sheets2012

    • Author(s)
      Ryo Sasaki, Masayuki Yamato, Ryo Takagi, Takashi Ohki, Hajime Matsumine, Teruo Okano, Tomohiro Ando
    • Organizer
      XXI Congress of the European Associstion for Cranio-Maxillo-Facial Surgery
    • Place of Presentation
      クロアチア
    • Related Report
      2012 Research-status Report
  • [Presentation] 顔面神経再生研究におけるラット顔面神経欠損モデル2012

    • Author(s)
      佐々木亮 松峯元 渡辺頼勝
    • Organizer
      第35回日本顔面神経研究会
    • Place of Presentation
      福島
    • Related Report
      2012 Research-status Report
  • [Presentation] SURGICAL ANATOMY OF THE SWINE FACE FOR MAXILLOFACIAL SURGERY2011

    • Author(s)
      Ryo Sasaki, Yorikatsu Watanabe, Hajime Matsumine, Masayuki Yamato, Teruo Okano, Tomohiro Ando
    • Organizer
      20th International Conference on Oral and Maxillofacial Surgery
    • Place of Presentation
      Santiago, Chile
    • Related Report
      2013 Final Research Report
  • [Presentation] ティッシュ・エンジニアリングのためのブタ顔面外科解剖2011

    • Author(s)
      佐々木亮, 渡辺頼勝, 安藤智博
    • Organizer
      第65回NPO法人日本口腔科学会学術集会
    • Place of Presentation
      東京都タワーホール船越
    • Related Report
      2013 Final Research Report
  • [Presentation] 歯髄を細胞ソースとした神経再生2011

    • Author(s)
      佐々木亮, 青木俊介, 大和雅之, 渡辺頼勝, 松峯元, 内山博人, 扇内秀樹, 和田圭司, 岡野光夫, 安藤智博
    • Organizer
      第36回日本外科系連合学会学術集会
    • Place of Presentation
      ヒルトン東京ベイ,千葉
    • Related Report
      2013 Final Research Report
  • [Presentation] Surgical anatomy of the swine face for maxillofacial surgery2011

    • Author(s)
      Ryo Sasaki
    • Organizer
      20th International Conference on Oral and Maxillofacial Surgery
    • Place of Presentation
      Santiago, Chile,
    • Related Report
      2011 Research-status Report
  • [Presentation] 歯髄を細胞ソースとした神経再生

    • Author(s)
      佐々木亮
    • Organizer
      第36回日本外科系連合学会学術集会(招待講演)
    • Place of Presentation
      ヒルトン東京ベイ, 千葉
    • Related Report
      2011 Research-status Report

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Published: 2011-08-05   Modified: 2019-07-29  

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