Roles of adrenoceptor subtypes in the regulation of accumbal dopaminergic activity

• Project/Area Number: 23792387
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Surgical dentistry
• Research Institution: Nihon University
• Principal Investigator: UCHIDA Takuya 日本大学, 歯学部, 助教 (10409104)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000); Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: アドレナリン受容体 / カテコラミン / 側坐核 / オーラルジスキネジア / ノルアドレナリン / ドパミン / 口腔ジスキネジア / ラット

Research Abstract

Oral dyskinesia is a neurological disorder characterized by repetitive stereotyped oral movements. The detailed biological basis of the symptom remains unclear, but behavioural studies suggest that accumbal dopaminergic neurons play a pivotal role in the induction of repetitive jaw movements of rats. It is known that there exists a close noradrenaline?dopamine interaction within this nucleus. In the present study, therefore, we analyzed the role of the adrenoceptor subtypes in the regulation of accumbal noradrenergic and dopaminergic activity in freely moving rats, using the in vivo brain microdialysis technique.

Research Products

• [Journal Article] The α1-, but not α2- adrenoceptor in the nucleus accumbens plays an inhibitory role upon the accumbal noradrenaline and dopamine efflux of freely moving rats. (2012)
  • Author(s): Saigusa T, Aono Y, Uchida T, Takada K, Verheij MMM, Koshikawa N, Cools A R.
  • Journal Title: Eur J Pharmacol Volume: 688 Pages: 35-41
  • Peer Reviewed
• [Journal Article] In vivo neurochemical evidence that newly synthesised GABA activates GABA_B, but not GABA_A, receptors on dopaminergic nerve endings in the nucleus accumbens of freely moving rats. (2012)
  • Author(s): Saigusa T, Aono Y, Sekino R, Uchida T, Takada K, Oi Y, Koshikawa N, Cools AR.
  • Journal Title: Neuropharmacology Volume: 62 Pages: 907-913
  • Peer Reviewed
• [Journal Article] The α1-, but not α2-, adrenoceptor in the nucleus accumbens plays an inhibitory role upon the accumbal noradrenaline and dopamine efflux of freely moving rats (2012)
  • Author(s): Tadashi Saigusa
  • Journal Title: European Journal of Pharmacology Volume: 688 Pages: 35-41
  • Peer Reviewed
• [Journal Article] In vivo neurochemical evidence that newly synthesised GABA activates GABAB, but not GABAA, receptors on dopaminergic nerve endings in the nucleus accumbens of freely moving rats (2012)
  • Author(s): Tadashi Saigusa
  • Journal Title: Neuropharmacology Volume: 62 Pages: 907-913
  • Peer Reviewed
• [Journal Article] but notseparate, stimulation of accumbal β1- and β2-adrenoceptors alters the accumbal dopamine efflux in freely moving rats.
  • Author(s): Saigusa T, Aono Y, Uchida T, Takada K, Koshikawa N, Cools A R. Synergistic
  • Journal Title: Eur J Pharmacol Volume: (in press)
  • Peer Reviewed
• [Presentation] Simultaneous, but not separate activation of beta-1?and beta-2?adrenoceptors in the nucleus accumbens increases accumbal dopamine efflux in freely moving rats (2012)
  • Author(s): Uchida T.
  • Organizer: 28th The International College of Neuropsychopharmacology (CINP), Stockholmsmassan
  • Place of Presentation: Stockholm, Sweden
  • Year and Date: 2012-06-06
• [Presentation] The alpha-1 adrenoceptor in the nucleus accumbens exerts an inhibitory control upon the accumbal noradrenaline and dopamine efflux in freely moving rats (2011)
  • Author(s): Uchida T.
  • Organizer: 2nd Congress of Asian College ofNeuropsychopharmacology Jointly with 2011Annual Meeting of Korean College ofNeuropsychopharmacology
  • Place of Presentation: Grand Hilton Seoul Hotel,Seoul, Korea
  • Year and Date: 2011-09-24
• [Presentation] The alpha-1 adrenoceptor in the nucleus accumbens exerts an inhibitory control upon the accumbal noradrenaline and dopamine efflux in freely moving rats (2011)
  • Author(s): Tadashi Saigusa
  • Organizer: 2nd Congress of Asian College of Neuropsychopharmacology Jointly with 2011 Annual Meeting of Korean College of Neuropsychopharmacology
  • Place of Presentation: Seoul (Korea)
• [Presentation] Simultaneous, but not separate activation of beta-1 and beta-2 adrenoceptors in the nucleus accumbens increases accumbal dopamine efflux in freely moving rats
  • Author(s): Yuri Aono
  • Organizer: 28th The International College of Neuropsychopharmacology (CINP)
  • Place of Presentation: Stockholm, Sweden
• [Remarks] 研究内容の平易な紹介
  • URL: http://www.bitway.ne.jp/ejournal/biglobe/2425100899.html