Roles of adrenoceptor subtypes in the regulation of accumbal dopaminergic activity
| Project/Area Number |
23792387
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Surgical dentistry
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| Research Institution | Nihon University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | アドレナリン受容体 / カテコラミン / 側坐核 / オーラルジスキネジア / ノルアドレナリン / ドパミン / 口腔ジスキネジア / ラット |
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| Research Abstract |
Oral dyskinesia is a neurological disorder characterized by repetitive stereotyped oral movements. The detailed biological basis of the symptom remains unclear, but behavioural studies suggest that accumbal dopaminergic neurons play a pivotal role in the induction of repetitive jaw movements of rats. It is known that there exists a close noradrenaline?dopamine interaction within this nucleus. In the present study, therefore, we analyzed the role of the adrenoceptor subtypes in the regulation of accumbal noradrenergic and dopaminergic activity in freely moving rats, using the in vivo brain microdialysis technique.
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Report
(3 results)
Research Products
(10 results)
