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Elucidation of the effect of the volatile anesthetics in the mechanism of the cell death by the myocardial ischemia-reperfusion injury

Research Project

Project/Area Number 23792396
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Surgical dentistry
Research InstitutionOsaka Dental University

Principal Investigator

INAMURA Yoshitaka  大阪歯科大学, 歯学部, 講師(非常勤) (80595794)

Project Period (FY) 2011 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords虚血性心疾患 / 心筋保護 / 揮発性麻酔薬 / オートファジー / アポトーシス
Research Abstract

Sevoflurane postconditioning reduced the infarct size by induction of autophagy. expression of LC3-II and the ratio of LC3-II/I were significantly increased in sevoflurane groups. Administration of 3-MA abolished these cardioprotective effects of sevofluranegroups. Expression of LC3-II and the ratio of LC3-II/I were significantly increased in POST and POST-L. Administration of 3-MA abolished these cardioprotective effects of POST. Sevoflurane postconditioning induces autophagy which plays an important role in cardioprotection against IR.

Report

(3 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Research-status Report
  • Research Products

    (16 results)

All 2012 2011 Other

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (14 results)

  • [Journal Article] Sevoflurane confers additive cardioprotection to ethanol preconditioning associated with enhanced phosphorylation of glycogen synthase kinase-3s and inhibition of mitochondrial permeability transitionpore opening2012

    • Author(s)
      Onishi A, Miyamae M, Inoue H, Kaneda K, Okusa C, Inamura Y, Shiomi M, Koshinuma S, Momota Y, Figueredo VM
    • Journal Title

      J Cardiothorac Vasc Anesth

      Volume: - Issue: 5 Pages: 916-924

    • DOI

      10.1053/j.jvca.2012.10.002

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Sevoflurane Confers Additive Cardioprotection to Ethanol Preconditioning Associated With Enhanced Phosphorylation of Glycogen Synthase Kinase-3β and Inhibition of Mitochondrial Permeability Transition Pore Opening.2012

    • Author(s)
      Onishi A.
    • Journal Title

      J Cardiothorac Vasc Anesth.

      Volume: -

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Presentation] 心筋虚血再灌流障害におけるnecroptosisの関与2012

    • Author(s)
      越沼静
    • Organizer
      第40回日本歯科麻酔学会総会・学術集会
    • Place of Presentation
      アクロス福岡(福岡市)
    • Year and Date
      2012-10-06
    • Related Report
      2012 Final Research Report
  • [Presentation] セボフルランポストコンディショニングの虚血心筋保護効果にはオートファジーの誘導が必要である2012

    • Author(s)
      稲村吉高
    • Organizer
      第40回日本歯科麻酔学会総会・学術集会
    • Place of Presentation
      アクロス福岡(福岡市)
    • Year and Date
      2012-10-06
    • Related Report
      2012 Final Research Report
  • [Presentation] セボフルラン・エタノールによる心筋プレコンディショイングの細胞内メカニズムの解明2012

    • Author(s)
      大西杏奈
    • Organizer
      第9回日本歯科麻酔学会中国・四国地方会
    • Place of Presentation
      岡山大学(岡山市)
    • Year and Date
      2012-07-29
    • Related Report
      2012 Final Research Report
  • [Presentation] セボフルランポストコンディショニングの虚血心筋保護効果にはオートファジーの誘導が必要である2012

    • Author(s)
      稲村吉高
    • Organizer
      日本麻酔科学会第59回学術集会
    • Place of Presentation
      神戸国際会議場(神戸市)
    • Year and Date
      2012-06-08
    • Related Report
      2012 Final Research Report
  • [Presentation] 心筋虚血前のオートファジーの誘導は長時間虚血により消失したセボフルランプレコンディショニング効果を回復させる2012

    • Author(s)
      塩見真由美
    • Organizer
      日本麻酔科学会第59回学術集会
    • Place of Presentation
      神戸国際会議場(神戸市)
    • Year and Date
      2012-06-08
    • Related Report
      2012 Final Research Report
  • [Presentation] Sevoflurane postconditioning reduces myocardial ischemia-reperfusion injury by induction of autophagy in isolated guinea pig hearts2011

    • Author(s)
      Inamura Y
    • Organizer
      9th International Congress on Coronary Artery Disease (ICCAD) from Prevention to Intervention 2011
    • Place of Presentation
      Venive (Italy)
    • Year and Date
      2011-10-25
    • Related Report
      2012 Final Research Report
  • [Presentation] Dipyridamole-induced cardiac preconditioning persists for3 days after discontinuing therapy and is mediated through Akt activation2011

    • Author(s)
      Okusa C
    • Organizer
      9th International Congress on Coronary Artery Disease (ICCAD) from Prevention to Intervention 2011
    • Place of Presentation
      Venive (Italy)
    • Year and Date
      2011-10-25
    • Related Report
      2012 Final Research Report
  • [Presentation] Dipyridamole-induced cardiac preconditioning persists for 3 days after discontinuing therapy and is mediated through Akt activation.2011

    • Author(s)
      Okusa C.
    • Organizer
      9th International Congress on Coronary Artery Disease (ICCAD) from Prevention to Intervention 2011
    • Place of Presentation
      Venice (Italy)
    • Related Report
      2011 Research-status Report
  • [Presentation] Sevoflurane postconditioning reduces myocardial ischemia-reperfusion injury by induction of autophagy in isolated guinea pig hearts.2011

    • Author(s)
      Inamura Y.
    • Organizer
      9th International Congress on Coronary Artery Disease (ICCAD) from Prevention to Intervention 2011
    • Place of Presentation
      Venice (Italy)
    • Related Report
      2011 Research-status Report
  • [Presentation] 心筋虚血前のオートファジーの誘導は長時間虚血により消失したセボフルランプレコンディショニング効果を回復させる.

    • Author(s)
      塩見真由美
    • Organizer
      日本麻酔科学会第59回学術集会
    • Place of Presentation
      神戸国際会議場(神戸市)
    • Related Report
      2012 Annual Research Report
  • [Presentation] セボフルランポストコンディショニングの虚血心筋保護効果にはオートファジーの誘導が必要である.

    • Author(s)
      稲村吉高
    • Organizer
      日本麻酔科学会第59回学術集会
    • Place of Presentation
      神戸国際会議場(神戸市)
    • Related Report
      2012 Annual Research Report
  • [Presentation] セボフルラン・エタノールによる心筋プレコンディショイングの細胞内メカニズムの解明.

    • Author(s)
      大西杏奈
    • Organizer
      第9回日本歯科麻酔学会中国・四国地方会
    • Place of Presentation
      岡山大学(岡山市)
    • Related Report
      2012 Annual Research Report
  • [Presentation] セボフルランポストコンディショニングの虚血心筋保護効果にはオートファジーの誘導が必要である.

    • Author(s)
      稲村吉高
    • Organizer
      第40回日本歯科麻酔学会総会・学術集会
    • Place of Presentation
      アクロス福岡(福岡市)
    • Related Report
      2012 Annual Research Report
  • [Presentation] 心筋虚血再灌流障害におけるnecroptosisの関与.

    • Author(s)
      越沼 静
    • Organizer
      第40回日本歯科麻酔学会総会・学術集会
    • Place of Presentation
      アクロス福岡(福岡市)
    • Related Report
      2012 Annual Research Report

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Published: 2011-08-05   Modified: 2019-07-29  

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