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Molecular pathological study of IgG4-MOLPS

Research Project

Project/Area Number 23792404
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Surgical dentistry
Research InstitutionAichi Gakuin University (2013-2014)
Ogaki Women's College (2011-2012)

Principal Investigator

SAKUMA Hidenori  愛知学院大学, 歯学部, 非常勤講師 (60453065)

Project Period (FY) 2011-04-28 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2013: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
KeywordsIgG4関連多臓器リンパ増殖性疾患 / 免疫グロブリン遺伝子 / 自己免疫性疾患 / 慢性硬化性唾液腺炎 / 自己免疫性膵炎 / シェーグレン症候群 / VH family / mutation / 制御性T細胞 / 慢性唾液腺炎
Outline of Final Research Achievements

IgG4-MOLPS is to suggest the involvement of a steroid-responsive autoimmune. This disease it was examined whether having the characteristics of autoimmune. Immunoglobulin gene clone, in the study of somatic mutation rate, but was not observed characteristic clone, the somatic mutation rate was the same results and autoimmune disease. However, the characteristic factor in autoimmune disease it could not be confirmed. IgG4-MOLPS from this study the possibility of recognized not autoimmune disease that strongly support an association between autoimmune disease was considered to be low.

Report

(5 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (5 results)

All 2014 2013 2012 2011

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (4 results)

  • [Journal Article] Analysis of VH gene rearrangement and somatic hypermutation in type 1 autoimmune pancreatitis2012

    • Author(s)
      Okumura F, Sakuma H, Nakazawa T, Hayashi K, Naitoh I, Miyabe K, Yoshida M, Yamashita H, Ohara H, Inagaki H, Joh T.
    • Journal Title

      Pathology international

      Volume: 62 Issue: 5 Pages: 318-323

    • DOI

      10.1111/j.1440-1827.2012.02788.x

    • NAID

      10031185207

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Presentation] IgG4関連疾患における免疫グロブリン遺伝子CDR3領域に関する検討2014

    • Author(s)
      佐久間英規 大岩伊知郎 下郷和雄
    • Organizer
      第24回日本口腔内科学会学術大会
    • Place of Presentation
      九州大学医学部百年講堂
    • Year and Date
      2014-09-18
    • Related Report
      2014 Annual Research Report
  • [Presentation] 慢性硬化性唾液腺炎における免疫グロブリン遺伝子V領域に関する検討2013

    • Author(s)
      佐久間 英規, 宮部悟, 大岩伊知郎, 下郷和雄
    • Organizer
      日本口腔内科学会
    • Place of Presentation
      一橋記念講堂
    • Related Report
      2013 Research-status Report
  • [Presentation] IgG4関連多臓器リンパ増殖性疾患における分子病理学的検討2012

    • Author(s)
      佐久間英規 宮部悟 深野英夫 宮地斉 杉浦正幸 下郷和雄
    • Organizer
      第57回日本口腔外科学会学術大会
    • Place of Presentation
      横浜国際会議場
    • Related Report
      2012 Research-status Report
  • [Presentation] 自己免疫性膵炎における免疫グロブリン遺伝子重鎖可変領域解析2011

    • Author(s)
      佐久間英規, 奥村文浩, 稲垣宏
    • Organizer
      第51回日本リンパ網内系学会総会
    • Place of Presentation
      福岡
    • Related Report
      2011 Research-status Report

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Published: 2011-08-05   Modified: 2019-07-29  

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