| Project/Area Number |
23792412
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Orthodontic/Pediatric dentistry
|
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| Research Institution | Tohoku University |
|---|
Principal Investigator |
HOSHI Kenji 東北大学, 病院, 助教 (90569964)
|
|---|
| Project Period (FY) |
2011 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 歯科矯正学 / 骨細胞 / メカニカルストレス / CTGF / アポトーシス |
|---|
| Research Abstract |
We examined osteocyte response to mechanical stress focusing on CTGF and apoptosis. Compressive force loading increased CTGF expression, thereafter, apoptosis were induced in osteocytes. Moreover, we demonstrated that CTGF induces osteocyte apoptosis through activation of ERK1/2 pathway. These results, at least in part, revealed the mechanism of bone remodeling regulated by osteocytes under mechanical stress.
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