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Effect of peptide relating to food intake behavior on swallowing in the developmental process

Research Project

Project/Area Number 23792424
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Orthodontic/Pediatric dentistry
Research InstitutionNiigata University

Principal Investigator

NAKAMURA Yuki  新潟大学, 医歯学系, 助教 (70452779)

Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords嚥下 / 摂食 / ペプチド
Research Abstract

One of the factors to feel satiety is an increase in blood glucose. Increase in blood insulin level caused by an increase in blood glucose regulate feeding behavior. On the other hand, sweet taste stimulation induce transient insulin secretion before increase in blood glucose level(Cephalic Phase of Insulin Release;CPIR).
In the present study, I investigated the effect of taste stimulation in the pharynx. Out of taste stimulants tested, acid solution facilitated initiation of swallow, in that the swallowing interval was significantly shorter during acid stimulation as compared to other taste ones. Sensory scale of taste intensity during swallowing was higher in acid solution. The results suggest that the effect of taste stimulation varies among tastants, and that acid stimulation may facilitate swallowing.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (18 results)

All 2014 2013 2012 2011

All Journal Article (10 results) (of which Peer Reviewed: 10 results) Presentation (8 results)

  • [Journal Article] 口腔への味溶液刺激がもたらす随意性嚥下への効果2014

    • Author(s)
      畠山文, 中村由紀, 真柄仁, 辻村恭憲, 谷口裕重, 堀一浩, 井上誠
    • Journal Title

      日本顎口腔機能学会雑誌

      Volume: (印刷中)

    • NAID

      130005061749

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] 口腔への味溶液刺激がもたらす随意性嚥下への効果2014

    • Author(s)
      畠山 文,中村由紀,真柄 仁,辻村恭憲,谷口裕重,堀 一浩,井上 誠
    • Journal Title

      日本顎口腔機能学会雑誌

      Volume: 印刷中

    • NAID

      130005061749

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effect of pharyngeal water stimulation on swallowing behavior in healty humans.2013

    • Author(s)
      Y Nakamura, A Hatakeyama, Y Kitada, T Tsujimura, H Taniguchi, M Inoue
    • Journal Title

      Exp Brain Res.

      Volume: 230(2) Issue: 2 Pages: 197-205

    • DOI

      10.1007/s00221-013-3641-y

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effects of chewing and swallowing behavior on jaw opening reflex responses in naturally feeding rabbits2013

    • Author(s)
      Aki Yamada
    • Journal Title

      Neuroscience Letters

      Volume: 535 Pages: 73-77

    • DOI

      10.1016/j.neulet.2012.12.047

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Differential involvement of two cortical masticatory areas in modulation of the swallowing reflex in rats2012

    • Author(s)
      T Tsujimura, K Tsuji, S Ariyasinghe, T Fukuhara, A Yamada, H Hayashi, Y Nakamura, K Iwata, M Inoue
    • Journal Title

      Neurosci Lett

      Volume: 528(2) Issue: 2 Pages: 159-164

    • DOI

      10.1016/j.neulet.2012.09.005

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Individual-dependent effects of pharyngeal electrical stimulation on swallowing in healthy humans2012

    • Author(s)
      H Tsukano, H Taniguchi, K Hori, T Tsujimura, Y Nakamura, M Inoue
    • Journal Title

      Physiol Behav

      Volume: 15 ; 106(2) Issue: 2 Pages: 218-223

    • DOI

      10.1016/j.physbeh.2012.02.007

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effects of pharyngeal electrical stimulation on the voluntary swallow in humans.2012

    • Author(s)
      Tsukano H, Taniguchi H, Hori K, Tsujimura T, Nakamura Y, Inoue M
    • Journal Title

      Physiology and behavior

      Volume: 106(2) Pages: 218-223

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] The Digastric Muscle is Less Involved in Pharyngeal Swallowing in Rabbits2011

    • Author(s)
      Tsujimura T, Yamada A, Nakamura Y, Fukuhara T, Yamamura K, Inoue M
    • Journal Title

      Dysphagia

      Volume: 印刷中 Issue: 2 Pages: 271-276

    • DOI

      10.1007/s00455-011-9363-z

    • Related Report
      2013 Final Research Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] ヒトの反射嚥下を誘発する末梢の化学刺激とその中枢調節機構2011

    • Author(s)
      川本健介, 井上拓哉, 成松花弥, 中村由紀, 井上誠, 矢作理花, 北田康之
    • Journal Title

      日本味と匂学会誌

      Volume: 18(3) Pages: 335-338

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] ヒトの反射嚥下を誘発する末梢の化学刺激とその中枢調節機構.2011

    • Author(s)
      川本健介,井上拓哉,成松花弥,中村由紀,井上 誠,矢作 理花,北田泰之
    • Journal Title

      日本味と匂学会誌

      Volume: 18(3) Pages: 335-338

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Presentation] 口腔咽頭領域への化学刺激がもたらす嚥下機能の変調効果2013

    • Author(s)
      中村由紀
    • Organizer
      第55回日本歯科基礎医学会学術大会サテライトシンポジウム
    • Place of Presentation
      岡山
    • Year and Date
      2013-09-20
    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Presentation] Effect of acid inputs in the pharynx on human swallowing2013

    • Author(s)
      Y Nakamura, A Hatakeyama, C Kanda, M Inoue
    • Organizer
      3rd Congress of the European Society for Swallowing Disorders
    • Place of Presentation
      Malmö Sweden
    • Related Report
      2013 Final Research Report
  • [Presentation] Effect of acid inputs in the pharynx on human swallowing.2013

    • Author(s)
      Y Nakamura, A Hatakeyama, C Kanda, M Inoue
    • Organizer
      3rd Congress of the European Society for Swallowing Disorders
    • Place of Presentation
      Malmo, Sweden
    • Related Report
      2013 Annual Research Report
  • [Presentation] ヒト咽頭部への化学刺激による随意性・反射性嚥下への効果2012

    • Author(s)
      中村由紀, 畠山文, 矢作理花, 井上誠
    • Organizer
      日本顎口腔機能学会第49回学術大会
    • Place of Presentation
      北九州
    • Related Report
      2013 Final Research Report 2012 Research-status Report
  • [Presentation] 筋電図および咽頭への微量液体注入を用いた随意性嚥下誘発能の評価2012

    • Author(s)
      中村由紀, 畠山文, 井上誠, 矢作理花
    • Organizer
      第17・18回共催日本摂食・嚥下リハビリテーション学会学術大会
    • Place of Presentation
      札幌
    • Related Report
      2013 Final Research Report
  • [Presentation] Chemical stimulation of the pharynx to trigger the swallowing reflex and it's inter-individual variation in humans2012

    • Author(s)
      Y Nakamura, A Hatakeyama, R Yahagi, M Inoue, Y Kitada
    • Organizer
      16^<th> International Symposium on Olfaction and Taste
    • Place of Presentation
      Stockholm, Sweden
    • Related Report
      2013 Final Research Report
  • [Presentation] Chemical stimulation of the pharynx to trigger the swallowing reflex and its inter-individual variation in humans2012

    • Author(s)
      Y Nakamura, A Hatakeyama, R Yahagi, M Inoue, Y Kitada
    • Organizer
      16th International Symposium on Olfaction and Taste
    • Place of Presentation
      Stockholm Sweden
    • Related Report
      2012 Research-status Report
  • [Presentation] 筋電図および咽頭への微量液体注入を用いた随意性嚥下誘発能の評価2012

    • Author(s)
      中村由紀,畠山 文,井上 誠,矢作理花
    • Organizer
      第17回・第18回共催日本摂食・嚥下リハビリテーション学会学術大会
    • Place of Presentation
      札幌
    • Related Report
      2012 Research-status Report

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Published: 2011-08-05   Modified: 2019-07-29  

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