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Susceptibility for amoxicillin in oral bacteria harbored in the subjects at risk for infective endocarditis

Research Project

Project/Area Number 23792425
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Orthodontic/Pediatric dentistry
Research InstitutionOsaka University

Principal Investigator

NEMOTO Hirotoshi  大阪大学, 歯学部附属病院, 医員 (80527226)

Project Period (FY) 2011 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Keywords感染性心内膜炎 / 先天性心疾患 / 術前投与 / アモキシシリン / デンタルプラーク / 耐性菌 / ペニシリン / 口腔レンサ球菌 / ペニシリン結合タンパク / 抗生物質耐性菌
Research Abstract

The prevalence of amoxicillin-resistant oral streptococcal strains in dental plaque specimens collected from Japanese individuals showed that approximately 5%of the healthy individuals harbored these strains. On the other hand, the detection rate of the subjects at risk for IE was approximately 20%. These amoxicillin-resistant strains tend to be resistant to other antibiotics. The additional large-scale studies regarding the distribution of the amoxicillin-resistant strains in the subject at risk for IE should be required.

Report

(3 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Research-status Report
  • Research Products

    (11 results)

All 2012 2011 Other

All Journal Article (5 results) (of which Peer Reviewed: 5 results) Presentation (5 results) Remarks (1 results)

  • [Journal Article] Amoxicillin-resistant oral streptococci identified in dental plaque specimens from healthy Japanese adults2012

    • Author(s)
      Masuda K, Nemoto H, Nakano K, Naka S, Nomura R, Ooshima T
    • Journal Title

      J Cardiol

      Volume: 59 Pages: 285-290

    • NAID

      10031187747

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Amoxicillin-resistant oral streptococci identified in dental plaque specimens from healthy Japanese adults.2012

    • Author(s)
      Masuda K, Nemoto H, Nakano K, Naka S, Nomura R, Ooshima T
    • Journal Title

      Journal of Cardiology

      Volume: 59(3) Issue: 3 Pages: 285-290

    • DOI

      10.1016/j.jjcc.2011.12.004

    • NAID

      10031187747

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Amoxicillin-resistant oral streptococci identified in dental plaque specimens from healthy Japanese adults.2012

    • Author(s)
      Masuda K, Nemoto H, Nakano K, et al.
    • Journal Title

      Journal of Cardiology

      Volume: In press

    • NAID

      10031187747

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Distribution of oral streptococci highly resistant to amoxicillin in dental plaque specimens from Japanese children and adolescents2011

    • Author(s)
      Nemoto H, Nakano K, Masuda K, Wada K, Ardin AC, Nomura R, Ooshima T
    • Journal Title

      J Med Microbiol

      Volume: 60 Pages: 1853-1859

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Distribution of oral streptococci highly resistant to amoxicillin in dental plaque specimens from Japanese chlidren and adolescents2011

    • Author(s)
      Nemoto H, Nakano K, Masuda K, Wada K, Ardin AC, Nomura R, Ooshima T.
    • Journal Title

      J Med Microbiol

      Volume: 60(12) Issue: 12 Pages: 1853-1859

    • DOI

      10.1099/jmm.0.027615-0

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Presentation] アモキシシリン耐性口腔レンサ球菌の母子伝播に関する分子生物学的検討2012

    • Author(s)
      根本浩利,野 村 良 太 ,仲野和彦
    • Organizer
      第31回日本小児歯科学会近畿地方会大会
    • Place of Presentation
      明石
    • Year and Date
      2012-10-14
    • Related Report
      2012 Final Research Report
  • [Presentation] Distribution of amoxicillin-resistant streptococci in dental plaque of Japanese adults2012

    • Author(s)
      Nemoto H, Nakano K, Masuda K, Nomura R, Ooshima T
    • Organizer
      90th IADR (International Association of Dental Research) Meeting
    • Place of Presentation
      Iguacu falls, Brazil
    • Year and Date
      2012-06-20
    • Related Report
      2012 Final Research Report
  • [Presentation] 日本人から採取したデンタルプラーク中におけるアモキシシリン耐性口腔レンサ球菌の分布2011

    • Author(s)
      増田勝彦,根本浩利,仲 周平,野村良太,仲野和彦,大嶋 隆
    • Organizer
      第30回日本小児歯科学会記念大会
    • Place of Presentation
      大阪
    • Year and Date
      2011-10-30
    • Related Report
      2012 Final Research Report 2011 Research-status Report
  • [Presentation] アモキシシリン耐性口腔レンサ球菌の母子伝播に関する分子生物学的検討

    • Author(s)
      根本浩利,野村良太,仲野和彦
    • Organizer
      第31回日本小児歯科学会近畿地方会大会
    • Place of Presentation
      兵庫県明石市
    • Related Report
      2012 Annual Research Report
  • [Presentation] Distribution of amoxicillin-resistant streptococci in dental plaque of Japanese adults.

    • Author(s)
      Hirotoshi Nemoto, Kazuhiko Nakano, Katsuhiko Masuda, Ryouta Nomura, Takashi Ooshima
    • Organizer
      90th IADR (International Association of Dental Research) Meeting
    • Place of Presentation
      Iguassu falls, Brazil
    • Related Report
      2012 Annual Research Report
  • [Remarks]

    • URL

      http://web.dent.osaka-u.ac.jp/~pedo/research/index.html

    • Related Report
      2012 Final Research Report

URL: 

Published: 2011-08-05   Modified: 2019-07-29  

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