Susceptibility for amoxicillin in oral bacteria harbored in the subjects at risk for infective endocarditis

• Project/Area Number: 23792425
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Orthodontic/Pediatric dentistry
• Research Institution: Osaka University
• Principal Investigator: NEMOTO Hirotoshi 大阪大学, 歯学部附属病院, 医員 (80527226)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2011: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
• Keywords: 感染性心内膜炎 / 先天性心疾患 / 術前投与 / アモキシシリン / デンタルプラーク / 耐性菌 / ペニシリン / 口腔レンサ球菌 / ペニシリン結合タンパク / 抗生物質耐性菌

Research Abstract

The prevalence of amoxicillin-resistant oral streptococcal strains in dental plaque specimens collected from Japanese individuals showed that approximately 5%of the healthy individuals harbored these strains. On the other hand, the detection rate of the subjects at risk for IE was approximately 20%. These amoxicillin-resistant strains tend to be resistant to other antibiotics. The additional large-scale studies regarding the distribution of the amoxicillin-resistant strains in the subject at risk for IE should be required.

Research Products

• [Journal Article] Amoxicillin-resistant oral streptococci identified in dental plaque specimens from healthy Japanese adults (2012)
  • Author(s): Masuda K, Nemoto H, Nakano K, Naka S, Nomura R, Ooshima T
  • Journal Title: J Cardiol Volume: 59 Pages: 285-290
  • NAID: 10031187747
  • Peer Reviewed
• [Journal Article] Amoxicillin-resistant oral streptococci identified in dental plaque specimens from healthy Japanese adults. (2012)
  • Author(s): Masuda K, Nemoto H, Nakano K, Naka S, Nomura R, Ooshima T
  • Journal Title: Journal of Cardiology Volume: 59(3) Issue: 3 Pages: 285-290
  • DOI: 10.1016/j.jjcc.2011.12.004
  • NAID: 10031187747
  • Peer Reviewed
• [Journal Article] Amoxicillin-resistant oral streptococci identified in dental plaque specimens from healthy Japanese adults. (2012)
  • Author(s): Masuda K, Nemoto H, Nakano K, et al.
  • Journal Title: Journal of Cardiology Volume: In press
  • NAID: 10031187747
  • Peer Reviewed
• [Journal Article] Distribution of oral streptococci highly resistant to amoxicillin in dental plaque specimens from Japanese children and adolescents (2011)
  • Author(s): Nemoto H, Nakano K, Masuda K, Wada K, Ardin AC, Nomura R, Ooshima T
  • Journal Title: J Med Microbiol Volume: 60 Pages: 1853-1859
  • Peer Reviewed
• [Journal Article] Distribution of oral streptococci highly resistant to amoxicillin in dental plaque specimens from Japanese chlidren and adolescents (2011)
  • Author(s): Nemoto H, Nakano K, Masuda K, Wada K, Ardin AC, Nomura R, Ooshima T.
  • Journal Title: J Med Microbiol Volume: 60(12) Issue: 12 Pages: 1853-1859
  • DOI: 10.1099/jmm.0.027615-0
  • Peer Reviewed
• [Presentation] アモキシシリン耐性口腔レンサ球菌の母子伝播に関する分子生物学的検討 (2012)
  • Author(s): 根本浩利,野 村 良 太 ,仲野和彦
  • Organizer: 第31回日本小児歯科学会近畿地方会大会
  • Place of Presentation: 明石
  • Year and Date: 2012-10-14
• [Presentation] Distribution of amoxicillin-resistant streptococci in dental plaque of Japanese adults (2012)
  • Author(s): Nemoto H, Nakano K, Masuda K, Nomura R, Ooshima T
  • Organizer: 90th IADR (International Association of Dental Research) Meeting
  • Place of Presentation: Iguacu falls, Brazil
  • Year and Date: 2012-06-20
• [Presentation] 日本人から採取したデンタルプラーク中におけるアモキシシリン耐性口腔レンサ球菌の分布 (2011)
  • Author(s): 増田勝彦,根本浩利,仲 周平,野村良太,仲野和彦,大嶋 隆
  • Organizer: 第30回日本小児歯科学会記念大会
  • Place of Presentation: 大阪
  • Year and Date: 2011-10-30
• [Presentation] アモキシシリン耐性口腔レンサ球菌の母子伝播に関する分子生物学的検討
  • Author(s): 根本浩利，野村良太，仲野和彦
  • Organizer: 第31回日本小児歯科学会近畿地方会大会
  • Place of Presentation: 兵庫県明石市
• [Presentation] Distribution of amoxicillin-resistant streptococci in dental plaque of Japanese adults.
  • Author(s): Hirotoshi Nemoto, Kazuhiko Nakano, Katsuhiko Masuda, Ryouta Nomura, Takashi Ooshima
  • Organizer: 90th IADR (International Association of Dental Research) Meeting
  • Place of Presentation: Iguassu falls, Brazil
• [Remarks]
  • URL: http://web.dent.osaka-u.ac.jp/~pedo/research/index.html