Analysis of Toll-like receptor signaling in Down syndrome with early onset periodontitis
| Project/Area Number |
23792426
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Orthodontic/Pediatric dentistry
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| Research Institution | Osaka University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2013: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | ダウン症候群 / 歯周炎 / TLR / 歯周疾患 / 障害者歯科 / 歯肉線維芽細胞 / 歯肉上皮細胞 / P.gingivalis |
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| Research Abstract |
Early onset periodontitis is likely to develop in young persons with Down syndrome. Toll-like receptors(TLR), which initiate key inflammatory responses, and their signaling was investigated in gingival cells derived from persons with Down syndrome. More TLRs and TLR signal molecules are expressed in the cells from Down syndrome than from non-Down syndrome. It seems that overreaction on immune system in Down syndrome is associated with early onset periodontitis.
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Report
(4 results)
Research Products
(16 results)
