Investigation of the mechanism of cartilage destruction induced by COX-2 in temporomandibular joint osteoarthrosis and establishment of anti-inflammatory drug treatment
| Project/Area Number |
23792429
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Orthodontic/Pediatric dentistry
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| Research Institution | Hiroshima University |
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Principal Investigator |
TANNE Yuki 広島大学, 大学院・医歯薬保健学研究院, 助教 (50526241)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 変形性顎関節症 / NSAID / 薬学 |
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| Research Abstract |
The excessive mechanical stress up-regulated COX-2 and MMP-1, 3, 9 in cultured chondrocyte derived from porcine condylar cartilage. Furthermore, the presence of Celecoxib decreased the gene expressions induced by mechanical stress. The presence of Celecoxib counteracted expressions of typeIIcollagen, aggrecan mRNA, however, the treatment of Indomethacin and Andamfenac sodium had no effect on these gene expression. Celecoxib showed a protective effect on extracellular matrix turnover by attenuating the influence of excessive mechanical stress on chondrocytes.
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Report
(3 results)
Research Products
(6 results)
