Development of new RNAi medicine for the chronic hereditary muscular disorder

• Project/Area Number: 23792431
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Orthodontic/Pediatric dentistry
• Research Institution: The University of Tokushima
• Principal Investigator: KINOUCHI Nao 徳島大学, 病院, 助教 (30457329)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2011: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
• Keywords: RNAi / 骨格筋 / コラーゲン

Research Abstract

We developed high special collagen of the certainty of the security supply that it was cheaper, and clinical application was possible as a substitute of atelocollagen where the effectiveness was confirmed as a siRNA introduction agent. The possibility that it was effective for the adjustment of the local skeletal muscle mass in the individual level was suggested when we introduced myostatin specific siRNA which was a skeletal muscle mass suppressor with this special collagen, and it was thought that we were connected for the development of the new cure for the chronicity hereditary muscular disorder in the future.