| Project/Area Number |
23792432
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Orthodontic/Pediatric dentistry
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| Research Institution | The University of Tokushima |
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Principal Investigator |
YASUE Akihiro 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 助教 (80380046)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2011: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
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| Keywords | 遺伝子医薬開発 / RNAi / Smad3 / 瘢痕形成抑制 / Smad3リン酸化抑制 / 創傷治癒促進 / SIS3 |
|---|
| Research Abstract |
Cleft palate patients are often subject to maxillary growth impairment and narrow dental arch after surgical closure of the defect in infancy. This is considered to be a consequence of the scar which is formed during palatal wound healing. Smad3 is one of the members concerned to TGF-・signaling pathway、and its deficient mice showed the notably accelerated wound healing in injured palates. In this study、we investigated the effects of the inhibition of Smad3 gene expression in wound repair、and as a result、an accelerated wound closure with down regulation of inflammatory genes was observed.
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