| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2013: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Outline of Final Research Achievements |
During orthodontic tooth movement, the bone metabolism of periodontal tissue is controlled by periodontal ligament cells. Osteoactivin (OA) was identified as the causative gene in an osteosclerosis rat model, and its osteogenetic role may enable bone formation of a periodontal ligament under tension. The inhibition of bone formation may cause bone resorption on the pressure side as well as the promotion of bone resorption.
In this study, we investigated the possibility that OA activation causes bone formation on the tension side through shedding of OA extracellular domain by ADAM12 and ADAM17. We also examined whether the expression and release of bone formation inhibitory factors as Asporin or SOST/sclerostin inhibited bone formation on the pressure side under either optimal or weak orthodontic forces
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