The effects of masticated alteration on brain and aging

• Project/Area Number: 23792444
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Orthodontic/Pediatric dentistry
• Research Institution: Showa University
• Principal Investigator: ENOMOTO AKIKO 昭和大学, 歯学部, 普通研究生 (60514982)
• Project Period (FY): 2011 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 脳機能 / 咀嚼 / 老化 / 行動解析 / 遺伝子発現 / 成長発育 / 脳発育

Research Abstract

Mastication is one of the most important oral functions, and the period during which mastication is acquired overlaps with the term of rapid development and maturation of the neural systems. However, the roles of mastication during this period for brain development remain largely unknown.
Therefore, we used a series of standard behavioral analyses, assessment of hippocampal cell proliferation, and the gene expression analysis of mice to investigate the effects of post-weaning mastication on brain function. Compared to mice fed a hard diet (HDM), soft-diet mice (SDM) showed behavioral impairment in prepulse inhibition, significantly decreased hippocampal cell proliferation and brain-derived neurotrophic factor(BDNF) gene expression. These results were similar to those observed in mouse models of schizophrenia. A soft diet after weaning may have resulted in histological and molecular changes in the hippocampus and influenced outcomes of behavioral tests related to mental disorders.

Research Products

• [Journal Article] Soft-diet feeding after weaning affects behavior in mice, potential increase in vulnerability to mental disorders (2014)
  • Author(s): Nose-Ishibashi K, Watahiki J, Yamada K, Maekawa M, Watanabe A, Yamamoto G, Enomoto A, Matsuba Y, Nampo T, Taguchi T, Ichikawa Y, Saido TC, Mishima K, Yamaguchi Y, Yoshikawa T, Maki K
  • Journal Title: Neuroscience Volume: 263(Accepted) Pages: 257-268
• [Journal Article] Soft-diet feeding after weaning affects behavior, hippocampal neurogenesis, and BDNF gene expression in mice : potential increased vulnerability to mental disorders (2014)
  • Author(s): Nose-Ishibashi K, Yamada K, Maekawa M, Yoshikawa T
  • Journal Title: Neuroscience Volume: 263 Pages: 257-268
  • DOI: 10.1016/j.neuroscience.2013.12.065
  • Peer Reviewed
• [Presentation] 成長発育期の軟食と精神疾患発症との関連性について(第二報) (2012)
  • Author(s): 野瀬佳奈, 綿引淳一, 山本剛, 市川雄大, 山田一之, 前川素子, 榎本明子, 南保友樹, 田口智博, 小野美樹, 美島健二, 吉川武男, 槇宏太郎
  • Organizer: 第71回日本矯正歯科学会学術大会プログラム抄録集
• [Presentation] Soft-diet feeding immediately after weaning results in a defi cit of prepulse inhibition and causes changes in the gene expression profi le in the brain of mice (2012)
  • Author(s): Junichi Watahiki, Kana Nose,Tomohiro Taguchi,Gou Yamamoto,Akiko Enomoto, Kazuyuki Yamada, Motoko Maekawa,Tomoki Nampo,Yuta Ichikawa,Miki Ono,Kenji Mishima,Takeo Yoshikawa,Koutaro Maki
  • Organizer: 第35回日本神経科学学会
• [Presentation] 離乳時からの軟食は精神疾患の発症リスクを高める可能性がある (2012)
  • Author(s): 野瀬佳奈, 綿引淳一, 山本剛, 市川雄大, 前川素子, 榎本明子, 南保友樹, 美島健二, 吉川武男, 槇宏太郎
  • Organizer: 第54回歯科基礎医学会学術大会学術集会プログラム抄録集
• [Presentation] Soft-diet feeding during development may increase vulnerability to mental disorders in mice (2012)
  • Author(s): Kana Ishibashi-Nose, Junichi Watahiki, Gou Yamamoto, Kazuyuki Yamada, Yuta Ichikawa, Motoko Maekawa, Akiko Enomoto, Tomoki Nampo, Tomohiro Taguchi, Miki Ono, Takeo Yoshikawa, Koutaro Maki
  • Organizer: Dental Medicine Research
• [Presentation] Influence of Soft-diet Feeding on Hippocampal Neurogenesis in Young Mice after Weaning (2012)
  • Author(s): Kana Ishibashi-Nose, Junichi Watahiki, Motoko Maekawa, Akiko Watanabe, Akiko Enomoto, Tomoki Nanpo, Tomohiro Taguchi, Yuta Ichikawa, Miki Ono, Koutaro Maki
  • Organizer: Dental Medicine Research
• [Presentation] 成長発育期の軟食と精神疾患発症との関連性について（第二報） (2012)
  • Author(s): 野瀬 佳奈、綿引 淳一、山本 剛、市川 雄大、山田 一之、榎本 明子、南保 友樹、田口 智博、小野 美樹、美島 健二、吉川 武男、槇 宏太郎
  • Organizer: 第71回日本矯正歯科学会
  • Place of Presentation: 盛岡
• [Presentation] Soft-diet feeding immediately after weaning results in a defi cit of prepulse inhibition and causes changes in the gene expression profi le in the brain of mice (2012)
  • Author(s): Junichi Watahiki, Kana Nose，Tomohiro Taguchi，Gou Yamamoto，Akiko Enomoto, Kazuyuki Yamada, Tomoki Nampo，Yuta Ichikawa，Kenji Mishima，Koutaro Maki
  • Organizer: 第35回日本神経科学学会
  • Place of Presentation: 名古屋
• [Presentation] 離乳時からの軟食は精神疾患の発症リスクを高める可能性がある (2012)
  • Author(s): 野瀬佳奈、綿引淳一、山本剛、市川雄大、榎本明子、南保友樹、美島健二、吉川武男、槇宏太郎
  • Organizer: 第54回歯科基礎医学会学術大会
  • Place of Presentation: 福島
• [Presentation] Influence of Soft-diet Feeding on Hippocampal Neurogenesis in Young Mice after Weaning (2011)
  • Author(s): Kana Ishibashi-Nose, Junichi Watahiki, Motoko Maekawa, Akiko Watanabe, Akiko Enomoto, Tomoki Nanpo, Tomohiro Taguchi, Yuta Ichikawa, Koutaro Maki
  • Organizer: 昭和歯学会
  • Place of Presentation: 東京
• [Presentation] Soft-diet feeding during development may increase vulnerability to mental disorders in mice
  • Author(s): Kana Ishibashi-Nose, Junichi Watahiki, Gou Yamamoto, Kazuyuki Yamada, Yuta Ichikawa, Akiko Enomoto, Tomoki Nampo, Tomohiro Taguchi, Miki Ono, Takeo Yoshikawa, Koutaro Maki
  • Organizer: 第32回昭和歯学会総会
  • Place of Presentation: 東京