| Project/Area Number |
23792444
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Orthodontic/Pediatric dentistry
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| Research Institution | Showa University |
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Principal Investigator |
ENOMOTO AKIKO 昭和大学, 歯学部, 普通研究生 (60514982)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 脳機能 / 咀嚼 / 老化 / 行動解析 / 遺伝子発現 / 成長発育 / 脳発育 |
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| Research Abstract |
Mastication is one of the most important oral functions, and the period during which mastication is acquired overlaps with the term of rapid development and maturation of the neural systems. However, the roles of mastication during this period for brain development remain largely unknown.
Therefore, we used a series of standard behavioral analyses, assessment of hippocampal cell proliferation, and the gene expression analysis of mice to investigate the effects of post-weaning mastication on brain function. Compared to mice fed a hard diet (HDM), soft-diet mice (SDM) showed behavioral impairment in prepulse inhibition, significantly decreased hippocampal cell proliferation and brain-derived neurotrophic factor(BDNF) gene expression. These results were similar to those observed in mouse models of schizophrenia. A soft diet after weaning may have resulted in histological and molecular changes in the hippocampus and influenced outcomes of behavioral tests related to mental disorders.
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