Abnormality of bone and cartilage by functional disorder of receptor mechanism in human PTH/PTHrP receptor
| Project/Area Number |
23792451
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Orthodontic/Pediatric dentistry
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| Research Institution | The Nippon Dental University |
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Principal Investigator |
SHIMOMURA JUNKO 日本歯科大学, 新潟生命歯学部, 准教授 (00386286)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Keywords | 骨 / 軟骨 / PTH-R / 遺伝子異常 / マウス / 遺伝子変異 |
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| Research Abstract |
The aim of this study was to elucidate the altered signaling pathway and abnormal cell differentiation caused by the PTH/PTHR receptor with H223R mutation (Jansen type PTH-R), which is overexpressed in murine bone and cartilage. Transgenic mice carrying Jansen type PTH-R were generated and histologically analyzed. As a consequence, the histological phenotype of bone and cartilage of Jansen type PTH-R transgenic mice was similar to the knockout mice of PTHrP or PTH-R.
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Report
(4 results)
Research Products
(34 results)
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[Journal Article] 日本小児歯科学会に属する女性小児歯科医への本音アンケート結果2012
Author(s)
馬場篤子, 渥美信子, 林-坂井幸子, 平野慶子, 人美さよ子, 小田訓子, 下村-黒木淳子, 仲野道代, 朝田芳信, 井上美津子, 斎藤秀子, 森榮, 吉田昊哲, 高野博子
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Journal Title
小児歯誌
Volume: 50巻
Pages: 383-392
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[Presentation] 日本小児歯科学会北日本地方会に所属する女性小児歯科医の本音トークアンケート結果-女性の私生活と仕事に関する調査-2011
Author(s)
齋藤珠美, 駿河由利子, 浅川麻美, 青山有子, 加川千鶴世, 林-坂井幸子, 佐野富子, 庄内喜久子, 土岐志麻, 福井亜美, 芳野素子, 下村-黒木淳子
Organizer
第29回日本小児歯科学会北日本地方会大会および総会
Place of Presentation
北海道
Year and Date
2011-10-29
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