| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Research Abstract |
The aim of this study was to elucidate the altered signaling pathway and abnormal cell differentiation caused by the PTH/PTHR receptor with H223R mutation (Jansen type PTH-R), which is overexpressed in murine bone and cartilage. Transgenic mice carrying Jansen type PTH-R were generated and histologically analyzed. As a consequence, the histological phenotype of bone and cartilage of Jansen type PTH-R transgenic mice was similar to the knockout mice of PTHrP or PTH-R.
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